| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LRAP; L-RAP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ERAP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ERAP2抗体的3篇示例性参考文献(注：文献为假设性概括，实际文献需通过学术数据库核实)：
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1. **文献名称**：*ERAP1 and ERAP2 synergize to generate MHC class I-associated peptides*
**作者**：Saveanu, L., et al.
**摘要**：本研究揭示了ERAP2与ERAP1在内质网中协同作用，通过剪切抗原前体肽生成适合MHC I类分子呈递的短肽。实验利用特异性抗体阻断ERAP2活性，证明其在抗原加工中不可或缺，为免疫治疗提供新靶点。
2. **文献名称**：*ERAP2 genetic variants alter protein structure and function in inflammatory diseases*
**作者**：Goto, Y., et al.
**摘要**：通过分析ERAP2基因多态性，发现特定突变导致其酶活性和底物特异性改变。研究采用抗ERAP2抗体进行蛋白质表达水平检测，揭示其与强直性脊柱炎等自身免疫疾病的关联机制。
3. **文献名称**：*ERAP2 regulates macrophage inflammatory responses via TLR4 signaling*
**作者**：Repekeviciute, M., et al.
**摘要**：研究利用ERAP2抗体敲低巨噬细胞中的ERAP2表达，发现其通过调控TLR4通路影响炎症因子分泌，提示ERAP2在感染和自身免疫中的双重作用，为靶向抗体开发提供依据。
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**建议**：可通过PubMed或Google Scholar检索关键词“ERAP2 antibody”、“ERAP2 inhibitor”或“ERAP2 function”获取最新研究。真实文献可能涉及抗体在疾病诊断、机制研究或治疗中的应用。
ERAP2 (Endoplasmic Reticulum Aminopeptidase 2) is a key enzyme involved in antigen processing for major histocompatibility complex class I (MHC-I) presentation. It trims precursor peptides in the endoplasmic reticulum to optimize their length and binding affinity for MHC-I molecules, enabling immune recognition by CD8+ T cells. ERAP2 operates in tandem with its homolog ERAP1. though their substrate preferences and trimming mechanisms differ. Genetic polymorphisms in ERAP2 have been linked to autoimmune and inflammatory diseases, including ankylosing spondylitis, Behçet's disease, and psoriasis, highlighting its role in immune regulation. Dysregulation of ERAP2 may also influence viral infection outcomes and cancer immunity by altering antigenic peptide repertoires.
Antibodies targeting ERAP2 are critical tools for studying its expression, localization, and functional interactions. They enable detection of ERAP2 in cellular models, assessment of enzymatic activity modulation, and exploration of disease-associated genetic variants. Specific ERAP2 antibodies (e.g., monoclonal clones like 4E7 or polyclonal variants) are validated for techniques including Western blotting, immunohistochemistry, and immunofluorescence. Recent research explores ERAP2 inhibition as a therapeutic strategy for autoimmune disorders or cancer immunotherapy, driving demand for high-specificity antibodies to evaluate drug efficacy. However, antibody performance may vary depending on epitope accessibility and species cross-reactivity, necessitating rigorous validation for experimental applications.
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