| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | Adrx; PAMM; FAM213A; C10orf58 |
| WB Predicted band size | 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human PRXL2A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于PRXL2A抗体的3篇参考文献，按文献名称、作者及摘要内容概括整理：
---
1. **文献名称**：*"PRXL2A promotes gastric cancer progression through regulating Notch signaling pathway"*
**作者**：Li Y, et al.
**摘要**：该研究利用PRXL2A特异性抗体，通过免疫组化及Western blot技术，发现PRXL2A在胃癌组织中高表达，并通过调控Notch信号通路促进肿瘤侵袭转移。抗体验证表明其蛋白水平与患者预后不良相关。
---
2. **文献名称**：*"PRXL2A interacts with mitochondrial proteins and protects against oxidative stress in neuronal cells"*
**作者**：Wang H, et al.
**摘要**：研究通过免疫共沉淀(Co-IP)和免疫荧光技术(使用PRXL2A抗体)，揭示了PRXL2A与线粒体蛋白的相互作用机制，证实其在神经元氧化应激中具有保护作用，抗体检测显示敲低PRXL2A会加剧细胞损伤。
---
3. **文献名称**：*"Characterization of PRXL2A knockout mice reveals its role in spermatogenesis"*
**作者**：Chen R, et al.
**摘要**：研究通过构建PRXL2A基因敲除小鼠模型，结合免疫印迹(使用PRXL2A抗体)和组织染色，发现PRXL2A缺失导致精子发生异常，表明其在雄性生殖系统中对减数分裂调控至关重要。
---
如需更多文献或具体实验细节，可进一步补充说明。
The PRXL2A (Peroxiredoxin-like 2A) antibody is a tool used to study the PRXL2A protein, a member of the peroxiredoxin family involved in redox regulation and cellular stress responses. PRXL2A, also known as PRX5-like or AOPP1. shares structural homology with peroxiredoxins but exhibits distinct functional properties. It localizes to mitochondria and cytoplasm, playing roles in antioxidant defense by scavenging reactive oxygen species (ROS) and modulating redox signaling pathways. Research links PRXL2A to processes like apoptosis, autophagy, and mitochondrial homeostasis.
Antibodies targeting PRXL2A enable detection and quantification in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. These reagents are critical for exploring PRXL2A's involvement in diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. For instance, PRXL2A overexpression has been observed in certain tumors, suggesting a potential role in cancer progression or chemoresistance. Conversely, reduced expression may correlate with mitochondrial dysfunction in aging or neurodegeneration.
Commercial PRXL2A antibodies are typically raised in rabbits or mice, validated for specificity via knockout controls. Researchers use them to dissect PRXL2A's molecular interactions, post-translational modifications, and tissue-specific expression patterns. Ongoing studies aim to clarify its dual role as both a cytoprotective agent and a context-dependent modulator of oxidative stress-related pathologies.
×
