| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ADC; CSADC; HuADC; HuCSADC |
| WB Predicted band size | 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human GADL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GADL1抗体的3篇参考文献示例(注：文献为虚拟示例，实际引用需核实)：
1. **"Characterization of GADL1-Specific Antibodies and Their Role in Detecting Tissue Expression"**
*作者：Chen et al.*
*摘要*：本研究开发了针对GADL1蛋白的高特异性多克隆抗体，通过Western blot和免疫组化分析，揭示了GADL1在肾脏和甲状腺中的高表达，提示其可能参与器官特异性代谢功能。
2. **"GADL1 as a Biomarker in Bipolar Disorder: Antibody-Based Detection and Clinical Correlation"**
*作者：Leck et al.*
*摘要*：利用GADL1抗体检测患者血清及脑组织样本，发现GADL1表达水平与双相情感障碍患者对锂盐治疗的反应性相关，提示其作为治疗预测标志物的潜力。
3. **"Comparative Analysis of GADL1 and GAD65 Autoantibodies in Type 1 Diabetes"**
*作者：Diana et al.*
*摘要*：通过比较GADL1与GAD65抗体的免疫反应性，发现糖尿病患者中GADL1抗体罕见，表明其在糖尿病自身免疫中的特异性低于GAD65.但可能与其他自身免疫疾病相关。
(注：若需真实文献，建议通过PubMed或Google Scholar以关键词“GADL1 antibody”、“GADL1 biomarker”检索。)
The glutamate decarboxylase-like protein 1 (GADL1) antibody is a tool used to detect and study GADL1. an enzyme belonging to the glutamate decarboxylase (GAD) family. Unlike its well-characterized homologs GAD65 and GAD67. which are critical for synthesizing the neurotransmitter gamma-aminobutyric acid (GABA) in the nervous system, GADL1 exhibits distinct biochemical properties and tissue expression. Primarily expressed in the kidneys, testes, and specific brain regions, GADL1 lacks classical GABA-producing activity but may participate in alternative metabolic pathways, such as synthesizing β-alanine or influencing cellular redox balance.
GADL1 antibodies are pivotal in research to elucidate the protein’s physiological roles. Studies suggest potential links to neuropsychiatric disorders, metabolic conditions, and renal function, though its exact mechanisms remain unclear. In autoimmune contexts, GAD antibodies (typically targeting GAD65/67) are biomarkers for type 1 diabetes and stiff-person syndrome, but GADL1 autoantibodies are less characterized. Emerging evidence hints at their possible association with certain autoimmune or neurological conditions, warranting further investigation.
Commercially available GADL1 antibodies are used in techniques like Western blotting, immunohistochemistry, and ELISA. Validation of antibody specificity is crucial due to structural similarities among GAD family members. Ongoing research aims to clarify GADL1’s functional significance and its potential as a diagnostic or therapeutic target.
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