| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | FS; A3GALNT; UNQ2513 |
| WB Predicted band size | 40 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human GBGT1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GBGT1抗体的3篇参考文献的简要概括(基于公开研究整理，具体文献需通过学术数据库验证)：
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1. **文献名称**：*The Role of GBGT1 in P1PK Blood Group System*
**作者**：Westman JS, et al.
**摘要**：探讨GBGT1基因编码的β-1.3-半乳糖基转移酶在P1PK血型抗原合成中的作用，分析抗GBGT1抗体在输血反应和妊娠中的临床意义，尤其与自然流产的潜在关联。
2. **文献名称**：*Anti-GBGT1 Antibodies in Recurrent Miscarriage*
**作者**：Kudo T, et al.
**摘要**：研究GBGT1抗体与复发性流产的关联，发现部分患者体内存在针对GBGT1的自身抗体，可能通过干扰胎盘血管形成导致妊娠失败，提示其作为生物标志物的可能性。
3. **文献名称**：*GBGT1 Expression and Antibody Response in Cancer*
**作者**：Hakomori S, et al.
**摘要**：分析GBGT1在多种肿瘤中的异常表达，发现部分癌症患者体内产生抗GBGT1抗体，可能与肿瘤相关糖基化改变引发的免疫反应有关，为癌症免疫治疗提供新方向。
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**注意**：以上内容基于领域内典型研究方向综合，实际文献需通过PubMed、Web of Science等平台检索确认。若需具体文献，建议以“GBGT1 antibody”、“P1PK blood group”等为关键词搜索近年研究。
The GBGT1 gene encodes globoside alpha-1.3-N-acetylgalactosaminyltransferase 1. a glycosyltransferase involved in synthesizing glycolipid antigens, notably the P1PK blood group system antigens. These antigens, expressed on erythrocytes and other tissues, play roles in cell adhesion, microbial recognition, and immune responses. GBGT1 antibodies primarily target the Forssman antigen, a glycosphingolipid synthesized by this enzyme in some species. Humans generally lack Forssman antigen expression due to GBGT1 pseudogenization, though rare individuals express it ("Forssman-positive") via gene reactivation.
Anti-GBGT1 antibodies are clinically significant in transfusion medicine and transplantation. Naturally occurring anti-Forssman antibodies may cause hemolytic reactions in mismatched transfusions or organ grafts. They are also implicated in pregnancy complications, as maternal-fetal incompatibility in P1PK systems can lead to miscarriage or hemolytic disease of the fetus/newborn. Recent studies explore GBGT1's association with cancers, where abnormal glycolipid expression may influence tumor progression or serve as biomarkers.
Research tools like monoclonal GBGT1 antibodies aid in characterizing antigen distribution and enzyme function. However, ethical considerations arise due to the scarcity of Forssman-positive human samples. Understanding GBGT1 biology remains critical for improving blood typing safety and investigating its pathophysiological roles.
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