| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SLC41A1-L2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SLC41A3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SLC41A3抗体的3篇参考文献示例(注：文献信息为虚构示例，实际引用需核实原文)：
1. **文献名称**：*SLC41A3 mediates magnesium transport in mammalian cells and its role in hypertension*
**作者**：Kolisek M. et al.
**摘要**：研究通过Western blot和免疫荧光技术验证SLC41A3抗体特异性，发现SLC41A3参与细胞镁离子外排，其表达异常与高血压病理相关。
2. **文献名称**：*SLC41A3 expression correlates with tumor progression in colorectal cancer*
**作者**：Zhou Y. et al.
**摘要**：利用SLC41A3抗体进行免疫组化分析，发现该蛋白在结直肠癌组织中高表达，与患者预后不良和转移相关。
3. **文献名称**：*Characterization of SLC41A3 cellular localization and function in cardiomyocytes*
**作者**：Schmitz C. et al.
**摘要**：通过抗体标记证实SLC41A3定位于心肌细胞线粒体膜，调控镁稳态，影响心脏收缩功能。
建议通过PubMed或Google Scholar检索真实文献，关键词：**SLC41A3 antibody**、**SLC41A3 function**。
The SLC41A3 antibody is a research tool targeting the solute carrier family 41 member 3 (SLC41A3), a transmembrane protein implicated in magnesium (Mg²⁺) transport and homeostasis. SLC41A3 belongs to the SLC41 family, which shares structural similarities with bacterial Mg²⁺ transporters, though its precise physiological role in mammals remains under investigation. Studies suggest SLC41A3 may function as a Na⁺/Mg²⁺ exchanger or participate in Mg²⁺ efflux mechanisms, potentially influencing cellular Mg²⁺ balance, mitochondrial function, and metabolic regulation. Dysregulation of SLC41A3 has been linked to cardiovascular diseases, neurodegenerative disorders, and cancer, highlighting its biomedical relevance.
The antibody, typically raised in rabbits or mice using immunogenic peptides or recombinant protein fragments, enables detection of SLC41A3 in various applications, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validation often involves knockout controls or siRNA-mediated knockdown to confirm specificity, as cross-reactivity with other SLC41 family members (e.g., SLC41A1/A2) must be ruled out. Researchers utilize this antibody to explore SLC41A3 expression patterns across tissues, its subcellular localization (plasma membrane, endoplasmic reticulum, or mitochondria), and its role in disease-associated Mg²⁺ dysregulation. However, variability in post-translational modifications or tissue-specific isoforms may require optimization of experimental conditions for reliable results.
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