| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GPR58; taR-2 |
| WB Predicted band size | 40 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human TAAR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及TAAR2抗体的文献摘要信息(基于现有研究推测，可能需核实具体文献)：
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1. **文献名称**: *"Characterization of a Novel Antibody for Trace Amine-Associated Receptor 2 (TAAR2) in Rodent Brain"*
**作者**: Smith A, et al.
**摘要**: 本研究开发并验证了一种针对TAAR2的特异性多克隆抗体，通过免疫组化和Western blot技术揭示了TAAR2在啮齿类动物大脑中的广泛表达，尤其在丘脑和下丘脑区域富集，支持其在神经调节中的潜在作用。
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2. **文献名称**: *"TAAR2 Expression in Human Peripheral Blood Monocytes: A New Tool for Immunological Studies"*
**作者**: Lee J, Kim H.
**摘要**: 文章报道了一种人源TAAR2抗体的开发，并利用流式细胞术和免疫荧光技术证实TAAR2在外周血单核细胞表面的表达，提示其可能参与免疫调节或炎症反应通路。
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3. **文献名称**: *"Antibody-Based Detection of TAAR2 in Schizophrenia Post-Mortem Brain Tissue"*
**作者**: Rossi M, et al.
**摘要**: 通过定制TAAR2抗体对精神分裂症患者尸检脑组织进行分析，发现TAAR2蛋白表达水平在前额叶皮层显著降低，提示其表达异常可能与精神疾病病理相关。
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(注：以上文献为示例性内容，实际文献需通过PubMed或Google Scholar以关键词“TAAR2 antibody”检索确认。)
**Background of TAAR2 Antibody**
TAAR2 (Trace Amine-Associated Receptor 2) is a G protein-coupled receptor (GPCR) belonging to the trace amine-associated receptor family. It is primarily expressed in the brain and binds trace amines, such as β-phenylethylamine and tyramine, which are structurally related to classical monoamine neurotransmitters. TAAR2 is implicated in modulating neurotransmitter systems, including dopamine and serotonin pathways, and has been linked to neuropsychiatric disorders like schizophrenia, depression, and bipolar disorder. However, its precise physiological role remains poorly understood due to low endogenous expression levels and overlapping functions with other TAAR subtypes.
TAAR2 antibodies are critical tools for studying the receptor's localization, expression patterns, and function in both normal and diseased states. These antibodies are typically developed against specific epitopes of the TAAR2 protein, such as extracellular or intracellular domains, and validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. Reliable TAAR2 antibodies help elucidate its involvement in neural signaling, synaptic plasticity, and potential therapeutic targeting. Challenges include ensuring specificity due to structural similarities among TAAR family members and low receptor abundance. Recent advancements in antibody validation techniques, including knockout controls and peptide-blocking assays, have improved their reliability in neuroscience research.
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