关键信息
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基因名
ANGPTL7/Angiopoietin-related 7
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简介
ANGPTL7/ Angiopoietin-related proteins are negative regulators of corneal angiogenesis and play an important role in maintaining the patency and transparency of corneal blood vessels. ANGPTL7 is regulated by SP1 transcription and regulates ANGPTL7 levels through the RhoA/ROCK signaling pathway mediating CLAN formation. ANGPTL7/Angiopoietin-related 7 Protein, Canine (HEK293, His) is the recombinant canine-derived ANGPTL7/Angiopoietin-related 7 protein, expressed by HEK293 , with C-His labeled tag.
- 应用
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别名
Angiopoietin-like factor; ANGPTL7; AngX; CDT6
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种属
Canine
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表达系统
HEK293
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
XP_852356.1
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表达区间
Q27-P344
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氨基酸序列
QKPLKRKTPGQLKVATCCEEAKELKAQIANLTSLLSELSKKQERDWVSVVMQVMELESSTKRMESRLTDAESKYSEMNNQIDIMQLQAAQTVTQTSADAIYDCSSLYQKNYRISGVYKLPPDDFLGSPELEVFCDMETAGGGWTIIQRRKSGLVSFYRDWKQYKQGFGSIRGDFWLGNEHIHRLSRRPTRLRVEMEDWEGSVRYAEYSRFVLGNELNSYRLFLGNYSGNVGNDALLYHNNTAFSTKDKDNDNCLDKCAQLRKGGYWYNCCTDSNLNGVYYRLGEHNKHLDGITWYGWHGSSYSLRRVEMKIRPEDFQP
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蛋白长度
Full Length of Mature Protein (with Propeptide)
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分子量
35 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
ANGPTL7 (Angiopoietin-like 7) is a member of the angiopoietin-like protein family, which plays a critical role in various physiological processes, including angiogenesis, inflammation, and metabolism. It is primarily expressed in the tissues of the eye, heart, and adipose tissue, implicating its potential significance in cardiovascular diseases and metabolic disorders. Recent studies have suggested that ANGPTL7 may influence lipid metabolism by modulating lipoprotein lipase activity, thereby impacting systemic lipid levels. Furthermore, its involvement in the regulation of inflammatory responses positions ANGPTL7 as a potential therapeutic target for conditions characterized by chronic inflammation and vascular dysfunction. The recombinant protein form of ANGPTL7 is being investigated to elucidate its biological functions and therapeutic potentials, particularly in the context of cardiovascular health and metabolic regulation. Understanding the mechanisms by which ANGPTL7 operates could pave the way for novel interventions in diseases where lipid metabolism and angiogenesis are disrupted, highlighting the need for ongoing research into its structure, function, and application in clinical settings.
