Rabbit Polyclonal KRT12 Antibody

Keratin 12 (KRT12) is a type I intermediate filament protein predominantly expressed in the corneal epithelium, where it pairs with KRT3 to form a structural framework essential for maintaining corneal integrity and mechanical stability. KRT12 antibodies are immunological tools designed to detect this tissue-specific keratin, playing a critical role in both research and diagnostic applications. Mutations in the KRT12 gene are linked to Meesmann epithelial corneal dystrophy (MECD), a rare autosomal dominant disorder characterized by fragile corneal epithelium, microcysts, and photophobia. KRT12 antibodies are widely used in immunohistochemistry (IHC), Western blotting, and immunofluorescence (IF) to assess protein expression patterns in corneal tissues, aiding in the study of corneal development, wound healing, and disease mechanisms. These antibodies help identify abnormal KRT12 expression or aggregation in corneal pathologies, enabling differential diagnosis of inherited corneal dystrophies. Additionally, they serve as biomarkers in preclinical studies evaluating corneal regeneration therapies or gene-editing approaches targeting KRT12 mutations. Monoclonal KRT12 antibodies offer high specificity, while polyclonal variants may detect conserved epitopes across species. Validation in species like humans, mice, and rabbits enhances their utility in translational research. Overall, KRT12 antibodies are indispensable for unraveling corneal biology and advancing therapeutic strategies for KRT12-related ocular disorders.