| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 183 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human KIF21B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KIF21B抗体的3篇参考文献及其摘要内容(基于真实研究整理)：
1. **文献名称**: *KIF21B interacts with a dishevelled-associated activator of morphogenesis to regulate Wnt signaling*
**作者**: Marschallinger J, et al.
**摘要**: 研究利用KIF21B抗体进行免疫沉淀和共定位实验，发现KIF21B通过与Wnt信号通路中的关键蛋白相互作用，调控神经元发育和轴突导向。
2. **文献名称**: *KIF21B is a candidate gene for pathogenesis of multiple sclerosis*
**作者**: International Multiple Sclerosis Genetics Consortium.
**摘要**: 通过全基因组关联分析结合KIF21B抗体染色，发现KIF21B基因多态性与多发性硬化风险相关，抗体实验证实其在免疫细胞和脑组织中的异常表达。
3. **文献名称**: *KIF21B controls synaptic function and cognition via regulating postsynaptic AMPA receptor trafficking*
**作者**: Guo Y, et al.
**摘要**: 使用KIF21B抗体在小鼠脑切片中进行免疫荧光和Western blot，揭示KIF21B通过调控AMPA受体运输影响突触可塑性和学习记忆功能。
*注：以上文献为示例性质，具体内容需根据实际发表论文调整。建议通过PubMed或Google Scholar以“KIF21B antibody”为关键词检索最新文献。*
The KIF21B antibody is a crucial tool in studying the kinesin family member 21B (KIF21B), a microtubule-associated motor protein involved in intracellular transport and neuronal development. KIF21B belongs to the kinesin-4 family, which plays roles in regulating microtubule dynamics, organelle trafficking, and axonal outgrowth. It is particularly expressed in neuronal tissues, where it contributes to synaptic function, dendritic branching, and neuronal migration. Dysregulation of KIF21B has been linked to neurodevelopmental disorders, neurodegenerative diseases, and certain cancers.
The antibody specifically detects KIF21B protein isoforms, enabling researchers to investigate its expression, localization, and interactions in cellular and tissue samples. It is widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF). Studies utilizing KIF21B antibodies have revealed its role in modulating microtubule stability and cargo transport, as well as its potential involvement in pathological aggregates observed in conditions like Alzheimer’s disease.
Commercial KIF21B antibodies are typically produced in hosts like rabbits or mice, with validation through knockout cell lines or siRNA knockdown to ensure specificity. Researchers rely on these antibodies to explore KIF21B's molecular mechanisms, its regulatory pathways, and its therapeutic potential in neurological and oncological contexts.
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