| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HH8; CPPB1; GPR54; AXOR12; KISS-1R; HOT7T175 |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human KISS1R |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KISS1R抗体的示例参考文献(仅供参考，实际文献请通过学术数据库查询)：
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1. **"Development and validation of a specific KISS1R polyclonal antibody for immunohistochemical analysis in human tissues"**
*作者：Smith A, et al.*
**摘要**：该研究开发了一种针对人类KISS1R的多克隆抗体，并通过免疫组化验证其在多种组织中的特异性表达，重点分析了生殖系统和脑区的分布模式。
2. **"KISS1R receptor expression in metastatic cancers: Role of a novel monoclonal antibody in detecting prognostic biomarkers"**
*作者：Chen L, et al.*
**摘要**：利用新型单克隆抗体探究KISS1R在转移性乳腺癌和前列腺癌中的表达水平，发现其高表达与肿瘤侵袭性降低相关，提示其潜在抑癌作用。
3. **"Characterization of KISS1R signaling in hypothalamic neurons using a phospho-specific antibody"**
*作者：Park J, et al.*
**摘要**：通过磷酸化特异性抗体研究KISS1R在下丘脑神经元中的激活机制，揭示了kisspeptin结合后受体下游的MAPK/ERK信号通路调控生殖激素分泌的分子机制。
4. **"Antibody-based targeting of KISS1R in polycystic ovary syndrome (PCOS) models"**
*作者：Gupta R, et al.*
**摘要**：评估抗KISS1R抗体在PCOS小鼠模型中的治疗潜力，证明其通过调节GnRH脉冲频率改善激素紊乱和卵巢功能障碍。
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**注意**：以上文献为示例，实际研究中请通过PubMed、Web of Science等平台检索关键词(如“KISS1R antibody”“GPR54 immunohistochemistry”)获取真实文献。
KISS1R (Kisspeptin Receptor), also known as GPR54. is a G protein-coupled receptor that binds kisspeptins, neuropeptides encoded by the KISS1 gene. Discovered in the early 2000s, KISS1R gained attention for its critical role in regulating the hypothalamic-pituitary-gonadal (HPG) axis, which controls puberty onset, reproductive hormone secretion, and fertility. Dysregulation of the KISS1/KISS1R system is linked to reproductive disorders like hypogonadotropic hypogonadism and precocious puberty. Additionally, KISS1R is implicated in cancer biology, as kisspeptins exhibit metastasis-suppressing properties in certain tumors.
Antibodies targeting KISS1R are essential tools for studying its expression, localization, and function in tissues. They enable detection via techniques like immunohistochemistry, Western blotting, and flow cytometry, aiding research into receptor distribution in the brain, gonads, and peripheral organs. However, developing specific KISS1R antibodies remains challenging due to the receptor’s structural homology with other GPCRs and low endogenous expression levels. Commercial antibodies vary in reliability, requiring validation with knockout controls or orthogonal methods. Current studies focus on leveraging KISS1R antibodies to explore therapeutic opportunities, such as modulating reproductive health or targeting cancer metastasis pathways. These efforts highlight KISS1R's dual significance in both physiology and disease, driving ongoing interest in refining antibody-based research tools.
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