Rabbit Polyclonal FN3KRP Antibody

FN3KRP (Fructosamine-3-Kinase-Related Protein) antibodies are tools used to study the FN3KRP protein, a homolog of fructosamine-3-kinase (FN3K). FN3KRP shares structural similarity with FN3K, including a conserved kinase-like domain, but lacks enzymatic activity due to critical amino acid substitutions in its active site. Discovered in 2004. FN3KRP is ubiquitously expressed, particularly in the liver, kidneys, and brain. Its biological role remains under investigation, though studies suggest involvement in mitigating non-enzymatic glycation—a process where sugars react with proteins, forming advanced glycation end-products (AGEs) linked to diabetic complications and aging. Unlike FN3K, which phosphorylates fructosamines to reverse glycation, FN3KRP may regulate glycation indirectly or participate in substrate recognition. Antibodies targeting FN3KRP enable detection, localization, and quantification in tissues or cell lysates via techniques like Western blot, immunohistochemistry, and ELISA. These reagents are critical for exploring FN3KRP’s physiological functions, its interaction with FN3K, and its potential role in metabolic disorders, neurodegeneration, or age-related diseases. Research using FN3KRP antibodies could clarify mechanisms of cellular stress responses and inform therapeutic strategies against glycation-associated pathologies.