| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | ALS9; HEL168; RNASE4; RNASE5 |
| WB Predicted band size | 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ANG |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ANG(angiogenin)抗体的3篇示例文献摘要(注：以下为模拟示例，实际文献需根据具体数据库检索)：
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1. **文献名称**: "Autoantibodies to Angiogenin in Amyotrophic Lateral Sclerosis: Diagnostic and Prognostic Implications"
**作者**: Yamada, A. et al. (2019)
**摘要**: 该研究检测了肌萎缩侧索硬化症(ALS)患者血清中抗ANG抗体的水平，发现其与疾病进展速度相关。研究提示抗ANG抗体可能作为ALS的生物标志物，并参与神经炎症反应调控。
2. **文献名称**: "Angiogenin-Specific Antibodies in Solid Tumors: Correlation with Angiogenesis and Clinical Outcomes"
**作者**: Lee, S. & Chen, X. (2020)
**摘要**: 通过分析实体瘤患者样本，研究发现抗ANG抗体的存在与肿瘤血管生成活性呈负相关，提示内源性抗ANG抗体可能通过抑制血管生成蛋白功能影响癌症预后。
3. **文献名称**: "Anti-ANG Autoantibodies in Systemic Lupus Erythematosus: Pathogenic Role and Epitope Mapping"
**作者**: Smith, J. et al. (2021)
**摘要**: 研究揭示了系统性红斑狼疮(SLE)患者中抗ANG抗体的高阳性率，并通过表位定位发现其靶向ANG的核定位信号区域，可能干扰细胞应激反应通路。
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如需真实文献，建议在PubMed或Web of Science中检索关键词："anti-angiogenin antibody"、"ANG autoantibody" 或结合具体疾病名称(如ALS、cancer)。
Angiogenin (ANG), a member of the RNase A superfamily, is a 14.4 kDa protein initially identified for its role in stimulating blood vessel formation (angiogenesis). Discovered in 1985. ANG is secreted under hypoxic or inflammatory conditions and binds to endothelial cells to promote neovascularization, a critical process in tumor growth and wound healing. Beyond angiogenesis, ANG exhibits ribonucleolytic activity, cleaving RNA to regulate stress response pathways. Notably, it processes transfer RNA (tRNA) into stress-induced tRNA-derived fragments (tiRNAs) during cellular stress, modulating translation and cell survival.
Dysregulation of ANG is implicated in cancer, neurodegenerative diseases (e.g., ALS), and inflammatory disorders. In cancer, elevated ANG levels correlate with tumor progression and metastasis. Conversely, ALS-linked ANG mutations impair its neuroprotective functions, disrupting RNA homeostasis and accelerating motor neuron degeneration.
ANG antibodies, developed for research and diagnostics, detect ANG expression in tissues or biological fluids, aiding studies on its pathological roles. Therapeutic strategies targeting ANG, including neutralizing antibodies, are under exploration to inhibit tumor angiogenesis or restore ANG function in neurodegenerative diseases. However, clinical applications remain limited, emphasizing the need for further research into ANG's complex biology and therapeutic potential.
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