| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SLEB11 |
| WB Predicted band size | 86 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human STAT4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于STAT4抗体的3篇参考文献示例(注：内容为虚构，仅用于演示格式)：
1. **文献名称**：*Autoantibodies against STAT4 in Systemic Lupus Erythematosus*
**作者**：Li, X., et al.
**摘要**：本研究首次报道系统性红斑狼疮(SLE)患者血清中存在抗STAT4自身抗体，并发现其与疾病活动度正相关，提示STAT4可能成为SLE的新型生物标志物。
2. **文献名称**：*STAT4 Phosphorylation Detection Using Monoclonal Antibodies in Rheumatoid Arthritis*
**作者**：Smith, J., & Tanaka, Y.
**摘要**：开发了一种高特异性STAT4磷酸化抗体，应用于类风湿关节炎患者外周血单核细胞的Western blot分析，证实IL-12信号通路中STAT4的异常激活与关节损伤相关。
3. **文献名称**：*Role of STAT4 in Th1 Differentiation: Insights from Antibody Blockade Experiments*
**作者**：Wang, H., et al.
**摘要**：通过STAT4中和抗体阻断实验，验证了STAT4在T细胞向Th1亚群分化中的关键作用，为靶向STAT4的免疫调节治疗提供理论依据。
(注：如需真实文献，建议通过PubMed或Google Scholar以“STAT4 antibody”或“STAT4 autoantibody”为关键词检索近年研究。)
**Background of STAT4 Antibody**
STAT4 (Signal Transducer and Activator of Transcription 4) is a member of the STAT protein family, which plays a critical role in cytokine-mediated signaling pathways. It is primarily activated by cytokines such as interleukin-12 (IL-12) and IL-23. triggering phosphorylation and dimerization to regulate gene expression. STAT4 is essential for the differentiation and function of T-helper 1 (Th1) and T-helper 17 (Th17) cells, influencing immune responses against pathogens and contributing to autoimmune diseases like rheumatoid arthritis, systemic lupus erythematosus (SLE), and inflammatory bowel disease (IBD).
Antibodies targeting STAT4 are widely used in research to detect its expression, phosphorylation status, and localization in cells or tissues. These antibodies enable techniques such as Western blotting, immunohistochemistry (IHC), and flow cytometry, aiding in studies of immune regulation, disease mechanisms, and therapeutic targeting. STAT4’s structure includes an SH2 domain critical for protein interactions and a tyrosine residue (Y693) essential for activation. Genetic polymorphisms in *STAT4* have been linked to increased disease susceptibility, making its study clinically relevant.
As dysregulated STAT4 signaling is implicated in autoimmunity and inflammation, STAT4 antibodies also serve as tools for developing diagnostics and evaluating inhibitors in preclinical models. Their specificity and reliability are vital for understanding STAT4’s role in health and disease.
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