Rabbit Polyclonal TLR8 Antibody

Toll-like receptor 8 (TLR8) is a key pattern recognition receptor in the innate immune system, primarily expressed in endosomes of immune cells like dendritic cells and macrophages. It recognizes single-stranded RNA (ssRNA) from viruses (e.g., SARS-CoV-2) and certain bacteria, triggering pro-inflammatory cytokine production and interferon responses to combat infections. TLR8 antibodies are critical tools for studying its expression, activation mechanisms, and regulatory roles in immune responses. These antibodies, often targeting extracellular or intracellular domains, are used in techniques like Western blotting, flow cytometry, and immunofluorescence to map TLR8 distribution, quantify expression levels, or inhibit its signaling in experimental models. Research highlights TLR8's dual role: while essential for antiviral defense, its overactivation is linked to autoimmune diseases (e.g., lupus) and chronic inflammation. Recent studies also explore TLR8 in cancer immunotherapy, as its modulation may enhance antitumor immunity. Species-specific antibodies (e.g., human, mouse) enable comparative studies across models. Challenges include ensuring antibody specificity due to structural homology with TLR7. Understanding TLR8 dynamics through antibody-based research aids in developing targeted therapies for infectious, inflammatory, and neoplastic diseases.