| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/500-1/5000 | Human,Mouse,Rat |
| Aliases | SL-1, STMY, STR1, CHDS6, MMP-3, STMY1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human MMP3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3条关于MMP3抗体的模拟参考文献示例(文献信息为虚构示例，仅供格式参考)：
1. **文献名称**: "Monoclonal antibody targeting MMP3 suppresses collagen degradation in osteoarthritis models"
**作者**: Smith A, et al.
**摘要**: 研究开发了一种特异性靶向MMP3的单克隆抗体，通过抑制其酶活性减少软骨细胞外基质降解。实验显示该抗体在小鼠骨关节炎模型中显著降低关节破坏，提示其潜在治疗价值。
2. **文献名称**: "MMP3 expression profiling in breast cancer using a novel immunohistochemical antibody"
**作者**: Lee J, et al.
**摘要**: 报道了一种高特异性MMP3抗体的开发及在乳腺癌组织中的验证。该抗体成功用于免疫组化检测，揭示MMP3在肿瘤侵袭边缘的高表达与患者预后不良相关。
3. **文献名称**: "Neutralizing MMP3 antibody attenuates post-infarction cardiac remodeling"
**作者**: Wang X, et al.
**摘要**: 通过中和性抗体阻断MMP3活性，显著减轻心肌梗死后心室纤维化及炎症反应。研究提示MMP3可能成为心血管修复的干预靶点。
**注意**：以上文献信息为示例性模拟，实际引用请通过PubMed、Web of Science等数据库检索真实文献。建议使用关键词"MMP3 antibody"+"therapeutic"或"MMP3 antibody"+"biomarker"进行精准检索。
**Background of MMP3 Antibody**
Matrix metalloproteinase 3 (MMP3), also known as stromelysin-1. is a member of the MMP family, a group of zinc-dependent endopeptidases involved in extracellular matrix (ECM) remodeling. MMP3 plays a critical role in degrading components like collagen, proteoglycans, and fibronectin, facilitating tissue repair, wound healing, and inflammatory responses. It is secreted as an inactive zymogen (pro-MMP3) and activated via proteolytic cleavage, regulating processes such as cell migration, angiogenesis, and tumor progression. Dysregulation of MMP3 is linked to pathologies including arthritis, cardiovascular diseases, and cancer metastasis.
MMP3 antibodies are essential tools for detecting and quantifying MMP3 expression in research and diagnostics. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and ELISA to study MMP3's role in disease mechanisms or therapeutic targeting. For example, elevated MMP3 levels in synovial fluid or serum serve as biomarkers for joint degradation in osteoarthritis or rheumatoid arthritis. Additionally, MMP3 antibodies aid in exploring its interaction with inhibitors (e.g., TIMPs) or signaling pathways in tumor microenvironments.
Developed against specific epitopes (e.g., catalytic domains or propeptide regions), these antibodies vary in specificity (monoclonal vs. polyclonal) and applications. Validation ensures minimal cross-reactivity with other MMPs, crucial for accurate data interpretation. Overall, MMP3 antibodies remain vital for advancing understanding of ECM dynamics and developing targeted therapies.
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