Rabbit Polyclonal CREB1 Antibody

The cAMP response element-binding protein 1 (CREB1) is a transcription factor that regulates gene expression in response to various cellular signals, including cAMP, calcium, and growth factors. It plays a critical role in processes like memory formation, circadian rhythm regulation, and cell survival. CREB1 antibodies are essential tools for detecting and studying this protein in research, enabling its localization, expression levels, and post-translational modifications (e.g., phosphorylation at Ser133) to be analyzed via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies typically target specific regions of CREB1. such as its N-terminal transactivation domain or the kinase-inducible domain (KID), which undergoes phosphorylation to activate transcription. Researchers use CREB1 antibodies to explore its involvement in diseases like cancer, neurodegenerative disorders, and mood disorders, where CREB1 dysregulation has been implicated. Validation of these antibodies is crucial, as cross-reactivity with related CREB family members (e.g., CREM or ATF1) may occur. Commercial CREB1 antibodies are often characterized in knockout models to ensure specificity. Understanding CREB1's role through antibody-based assays continues to advance insights into cellular signaling pathways and therapeutic target development.