| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CLG; CLGN |
| WB Predicted band size | 54 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human MMP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与MMP1抗体相关的模拟参考文献(内容基于常见研究方向概括，仅供参考)：
1. **"Monoclonal antibody targeting MMP1 inhibits tumor growth in a murine melanoma model"**
- **作者**: Smith A, et al.
- **摘要**: 研究开发了一种靶向MMP1的单克隆抗体，通过抑制MMP1的蛋白酶活性，显著减少黑色素瘤小鼠模型中的肿瘤侵袭和转移，提示其作为癌症治疗的潜在工具。
2. **"MMP1-specific antibody as a diagnostic biomarker in osteoarthritis"**
- **作者**: Lee JH, et al.
- **摘要**: 该文献报道了一种高特异性MMP1抗体的开发，用于检测骨关节炎患者关节液中的MMP1水平，证实其与疾病严重程度呈正相关，可作为临床诊断标志物。
3. **"Neutralizing MMP1 antibody attenuates pulmonary fibrosis in vitro and in vivo"**
- **作者**: Chen X, et al.
- **摘要**: 研究利用中和性MMP1抗体抑制肺成纤维细胞中胶原降解失衡，证明其在体外和肺纤维化小鼠模型中能减轻纤维化进程，为治疗纤维化疾病提供新策略。
4. **"Cross-reactivity analysis of commercial anti-MMP1 antibodies: implications for research reproducibility"**
- **作者**: Garcia R, et al.
- **摘要**: 分析了市售多种MMP1抗体的交叉反应性，发现部分抗体对MMP家族其他成员(如MMP8)存在非特异性结合，强调抗体验证对实验可重复性的重要性。
**注意**：以上内容为模拟生成，实际文献需通过PubMed、Web of Science等平台检索关键词(如“MMP1 antibody”“anti-MMP1 therapeutic”)。
**Background of MMP1 Antibody**
Matrix metalloproteinase 1 (MMP1), a member of the zinc-dependent endopeptidase family, plays a critical role in degrading extracellular matrix (ECM) components, particularly collagen types I, II, and III. It is involved in physiological processes like tissue remodeling, wound healing, and embryogenesis, as well as pathological conditions such as cancer metastasis, arthritis, and cardiovascular diseases. MMP1 is secreted as an inactive zymogen (pro-MMP1) and activated via proteolytic cleavage.
MMP1 antibodies are immunodetection tools designed to specifically target MMP1 in research and diagnostics. These antibodies, often monoclonal or polyclonal, enable the detection of MMP1 expression and localization in tissues or biological fluids using techniques like Western blotting, immunohistochemistry (IHC), and ELISA. They are essential for studying MMP1's role in diseases, particularly its overexpression in tumors, which correlates with poor prognosis and invasive potential.
Additionally, MMP1 antibodies aid in evaluating therapeutic interventions, such as MMP inhibitors, and serve as biomarkers for disease progression. Validation of antibody specificity is crucial, as MMPs share structural similarities, potentially leading to cross-reactivity. Ongoing research continues to refine MMP1 antibody applications in understanding ECM dynamics and developing targeted therapies.
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