| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | STAT6B; STAT6C; D12S1644; IL-4-STAT |
| WB Predicted band size | 94 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human STAT6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于STAT6抗体的3篇参考文献，按研究领域分类列举：
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### 1. **STAT6抗体在肿瘤诊断中的应用**
**文献名称**：*Nuclear Expression of STAT6 Distinguishes Solitary Fibrous Tumor from Histologic Mimics*
**作者**：Doyle LA, et al.
**摘要**：该研究验证了STAT6抗体作为孤立性纤维性肿瘤(SFT)的特异性标记物，通过免疫组化检测STAT6核表达，能有效区分SFT与其他形态相似的软组织肿瘤，如神经鞘瘤和滑膜肉瘤。
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### 2. **STAT6磷酸化与免疫应答机制研究**
**文献名称**：*STAT6 Signaling in Th2 Differentiation and Allergic Inflammation*
**作者**：Takeda K, et al.
**摘要**：探讨STAT6在Th2细胞分化中的核心作用，研究使用STAT6抗体检测其磷酸化状态，揭示IL-4/IL-13通过激活STAT6通路驱动过敏性炎症反应的分子机制。
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### 3. **STAT6抗体在肿瘤微环境中的功能研究**
**文献名称**：*Targeting STAT6 in Cancer-Associated Fibroblasts Inhibits Tumor Growth*
**作者**：Li JY, et al.
**摘要**：通过STAT6抗体阻断肿瘤相关成纤维细胞(CAFs)中的STAT6信号，发现可抑制肿瘤微环境中的免疫抑制因子分泌，增强抗肿瘤免疫反应，为STAT6靶向治疗提供实验依据。
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### 可选补充(第4篇)：
**文献名称**：*Optimization of STAT6 Detection for Flow Cytometry in Primary Immune Cells*
**作者**：Smith R, et al.
**摘要**：提出一种改良的流式细胞术方案，利用高特异性STAT6抗体检测免疫细胞内STAT6表达水平，解决了传统方法中交叉反应性强、信号弱的技术难点。
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**提示**：若需具体文献来源(期刊、年份)，可进一步补充数据库检索(如PubMed)。
STAT6 (Signal Transducer and Activator of Transcription 6) is a transcription factor that plays a critical role in mediating cellular responses to cytokines, particularly interleukin-4 (IL-4) and interleukin-13 (IL-13). Upon cytokine receptor activation, STAT6 is phosphorylated, leading to its dimerization, nuclear translocation, and regulation of target genes involved in immune regulation, inflammation, and cell differentiation. It is essential for T-helper 2 (Th2) cell development, allergic responses, and macrophage polarization.
STAT6 antibodies are widely used in research and diagnostics to detect STAT6 expression, phosphorylation status, and localization in cells or tissues. These antibodies enable the study of IL-4/IL-13 signaling pathways and their dysregulation in diseases such as asthma, allergies, and certain cancers. In oncology, STAT6 overexpression or constitutive activation has been linked to lymphoma subtypes and solid tumors. Notably, STAT6 immunohistochemistry is a key diagnostic tool for solitary fibrous tumors (SFTs), where a recurrent NAB2-STAT6 gene fusion results in nuclear STAT6 overexpression, aiding in distinguishing SFTs from histologic mimics.
Commercial STAT6 antibodies are typically developed against specific epitopes, including phosphorylated tyrosine residues (e.g., Tyr641) or the N-/C-terminal domains. Validation ensures specificity for applications like Western blotting, immunofluorescence, and immunohistochemistry. Understanding STAT6’s role and its detection via antibodies remains vital for unraveling disease mechanisms and advancing therapeutic strategies targeting cytokine signaling.
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