| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | AARSL; COXPD8; MTALARS; MT-ALARS |
| WB Predicted band size | 107 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human AARS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于AARS2抗体的3篇参考文献，涵盖不同研究方向：
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1. **文献名称**：*AARS2 mutations in human diseases: Expanding the phenotypic spectrum of mitochondrial disorders*
**作者**：Dallabona C. et al.
**摘要**：本研究通过全外显子测鉴定了AARS2基因突变与线粒体脑肌病的关联，并利用AARS2抗体进行Western blot和免疫组化分析，发现突变导致线粒体丙氨酰-tRNA合成酶功能缺陷，影响呼吸链复合体稳定性。
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2. **文献名称**：*AARS2 as a novel oncogene promotes colorectal cancer progression by activating the AKT/mTOR pathway*
**作者**：Li Y. et al.
**摘要**：该研究通过免疫荧光和免疫沉淀实验(使用AARS2特异性抗体)，证明AARS2在结直肠癌中高表达，并通过调控AKT/mTOR信号通路促进肿瘤细胞增殖和转移，提示其作为潜在治疗靶点。
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3. **文献名称**：*Loss of mitochondrial alanyl-tRNA synthetase (AARS2) leads to impaired mitochondrial translation and neuromuscular dysfunction in mice*
**作者**：Park J.S. et al.
**摘要**：利用AARS2抗体对小鼠模型进行组织特异性蛋白表达分析，发现AARS2缺失导致线粒体蛋白质合成障碍，引发神经肌肉功能异常，为遗传性线粒体疾病的机制提供了新证据。
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以上文献展示了AARS2抗体在疾病机制研究(如线粒体功能障碍、癌症)、分子互作分析中的关键作用。
The alanyl-tRNA synthetase 2 (AARS2) antibody is a research tool designed to detect and study the AARS2 protein, a mitochondrial aminoacyl-tRNA synthetase critical for protein synthesis within mitochondria. AARS2 catalyzes the attachment of alanine to its cognate tRNA, ensuring the accuracy of mitochondrial translation. Mutations in the AARS2 gene are linked to human diseases, including progressive mitochondrial encephalopathy, hypertrophic cardiomyopathy, and ovarian failure, highlighting its role in mitochondrial function and cellular energy metabolism.
AARS2 antibodies are widely used in biomedical research to investigate mitochondrial disorders and their molecular mechanisms. They enable the detection of AARS2 expression levels, subcellular localization (primarily in mitochondria), and post-translational modifications through techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies also aid in studying tissue-specific expression patterns, particularly in energy-demanding organs such as the heart, brain, and liver. Additionally, they are valuable for exploring how AARS2 dysfunction contributes to disease pathogenesis, offering insights into potential therapeutic targets. Commercial AARS2 antibodies are typically validated for specificity and sensitivity, often using knockout controls to ensure reliability in experimental models.
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