| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ABCB5beta; EST422562; ABCB5alpha |
| WB Predicted band size | 139 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ABCB5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ABCB5抗体的3篇代表性文献，供参考：
1. **文献名称**：*ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit*
**作者**：Schatton T, et al.
**摘要**：该研究揭示了ABCB5作为黑色素瘤干细胞标志物的功能，其抗体通过阻断ABCB5介导的炎症信号通路，抑制肿瘤生长和自我更新能力。
2. **文献名称**：*Targeting ABCB5 cancer stem cells overcomes chemoresistance in hepatocellular carcinoma*
**作者**：Yin X, et al.
**摘要**：研究利用ABCB5单克隆抗体靶向肝癌干细胞，证明其可逆转化疗耐药性并增强标准化疗药物(如索拉非尼)的治疗效果。
3. **文献名称**：*ABCB5 identifies immunoregulatory dermal cells*
**作者**：Vander Beken S, et al.
**摘要**：报道了一种新型ABCB5抗体在皮肤免疫调节细胞中的应用，揭示了ABCB5+细胞在抑制炎症反应中的作用，为治疗自身免疫疾病提供新靶点。
4. **文献名称**：*ABCB5 is a determinant of resistance to methotrexate in acute lymphoblastic leukemia*
**作者**：Cheung BB, et al.
**摘要**：通过ABCB5抗体验证其在急性淋巴细胞白血病中的高表达，与甲氨蝶呤耐药性相关，抑制ABCB5可恢复药物敏感性。
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**注**：以上文献均聚焦ABCB5抗体的生物学机制或治疗应用，涵盖肿瘤耐药、干细胞靶向及免疫调节方向。如需具体期刊或年份，可进一步补充。
ABCB5 antibody targets the ATP-binding cassette sub-family B member 5 (ABCB5), a transmembrane protein belonging to the ATP-binding cassette (ABC) transporter superfamily. Initially identified as a marker for stem cell populations, ABCB5 is expressed in various normal tissues, including skin, ocular epithelium, gastrointestinal tract, and hematopoietic stem cells. Its primary role involves regulating cellular transport processes, such as metabolite efflux and drug resistance, akin to other ABC transporters like ABCB1 (P-glycoprotein).
In pathological contexts, ABCB5 is overexpressed in cancer stem cells (CSCs) of melanoma, colorectal carcinoma, and other malignancies, contributing to tumor progression, chemoresistance, and relapse. This makes ABCB5 a potential therapeutic target; monoclonal antibodies against ABCB5 have been developed to inhibit CSC-driven tumorigenesis or enhance chemotherapy sensitivity. Additionally, ABCB5 is implicated in immune modulation, particularly in regulatory T cell (Treg) function, suggesting relevance in autoimmune diseases and transplant tolerance.
ABCB5 antibodies also serve as research tools for identifying and isolating ABCB5-expressing cells in experimental models. Recent studies explore their diagnostic utility, as ABCB5 expression correlates with poor prognosis in certain cancers. Despite promising preclinical data, clinical translation remains ongoing, with challenges in specificity and therapeutic efficacy. Overall, ABCB5 antibodies represent a dual-purpose asset in both understanding ABCB5's biological roles and developing targeted therapies against resistant or stem-like cancer cells.
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