Rabbit Polyclonal ALDOA Antibody

The ALDOA antibody targets aldolase A, a glycolytic enzyme encoded by the ALDOA gene. Aldolase A (ALDOA) catalyzes the cleavage of fructose-1.6-bisphosphate into triose phosphates during glycolysis and plays roles in cellular energy metabolism, cytoskeletal dynamics, and hypoxia response. It is highly expressed in muscle tissues and certain cancers, where its upregulation correlates with tumor progression, metastasis, and poor prognosis. ALDOA antibodies are widely used in research to study its expression patterns, subcellular localization, and functional roles in diseases. For example, they help identify ALDOA overexpression in cancers like lung, liver, or pancreatic carcinomas, supporting its potential as a diagnostic or prognostic biomarker. These antibodies also aid in exploring ALDOA's non-glycolytic functions, such as regulating cell adhesion or modulating signaling pathways. Commercially available ALDOA antibodies include monoclonal and polyclonal variants validated for techniques like Western blot, immunohistochemistry, and immunofluorescence. Recent studies also investigate ALDOA's involvement in rare genetic disorders, such as aldolase A deficiency linked to hemolytic anemia and myopathy. Its dual role in metabolism and disease makes ALDOA a compelling target for therapeutic development, with antibodies serving as critical tools for mechanistic and translational research.