| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CGI45; PAQR1; ACDCR1; CGI-45; TESBP1A |
| WB Predicted band size | 43 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ADIPOR1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于ADIPOR1抗体的参考文献示例(注：以下内容为模拟示例，非真实文献)：
1. **文献名称**：*ADIPOR1-mediated signaling improves insulin sensitivity in human skeletal muscle*
**作者**：Yamauchi T, et al.
**摘要**：通过ADIPOR1抗体进行Western blot和免疫组化分析，发现ADIPOR1在骨骼肌细胞膜上的表达与胰岛素敏感性正相关，激活ADIPOR1可增强AMPK通路，改善2型糖尿病模型中的糖代谢。
2. **文献名称**：*Tissue-specific distribution and function of ADIPOR1 in lipid metabolism*
**作者**：Kadowaki T, et al.
**摘要**：利用ADIPOR1特异性抗体研究其在小鼠肝脏、脂肪组织中的表达差异，证实ADIPOR1通过调节脂肪酸氧化和炎症因子分泌参与脂代谢调控，抗体阻断实验显示其缺失导致高脂血症。
3. **文献名称**：*ADIPOR1 as a potential therapeutic target in obesity-associated cancers*
**作者**：Wang Y, et al.
**摘要**：通过免疫荧光和流式细胞术(使用ADIPOR1单克隆抗体)，发现ADIPOR1在结肠癌组织中表达下调，其过表达可抑制肿瘤细胞增殖并诱导凋亡，机制与抑制mTOR通路相关。
4. **文献名称**：*Structural insights into ADIPOR1 activation by adiponectin*
**作者**：Okada-Iwabu M, et al.
**摘要**：采用ADIPOR1抗体进行共免疫沉淀和冷冻电镜分析，解析了ADIPOR1与脂联素结合的构象变化，揭示其通过跨膜结构域传递信号的结构基础。
(提示：实际文献需通过PubMed或学术数据库检索，以上示例为简化概括。)
ADIPOR1 (Adiponectin Receptor 1) is a transmembrane protein receptor that plays a critical role in regulating metabolic processes, including glucose and fatty acid metabolism. It binds to adiponectin, an adipocyte-derived hormone involved in insulin sensitivity, anti-inflammatory responses, and energy homeostasis. ADIPOR1 activates downstream signaling pathways such as AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor-alpha (PPARα), influencing cellular processes like mitochondrial biogenesis and oxidative stress modulation. Dysregulation of ADIPOR1 has been implicated in metabolic disorders (e.g., obesity, type 2 diabetes) and cardiovascular diseases.
Antibodies targeting ADIPOR1 are essential tools for studying its expression, localization, and function in tissues and cell lines. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate ADIPOR1's role in disease mechanisms or therapeutic interventions. Due to structural similarities between ADIPOR1 and its homolog ADIPOR2. antibody specificity is rigorously validated using knockout controls or siRNA-based approaches to avoid cross-reactivity. Recent studies also explore ADIPOR1's potential as a biomarker or therapeutic target, driving demand for high-affinity, well-characterized antibodies in both research and clinical applications.
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