Rabbit Polyclonal ABCB8 Antibody

The ABCB8 antibody is a crucial tool for studying the ATP-binding cassette (ABC) transporter subfamily B member 8. a protein encoded by the *ABCB8* gene. ABCB8. also known as mitochondrial ABCB8 or M-ABC1. is localized to the inner mitochondrial membrane and mitochondrial-associated membranes. It plays a vital role in mitochondrial homeostasis, including the transport of metabolites, iron-sulfur cluster biosynthesis, and protection against oxidative stress. Structurally, ABCB8 contains conserved nucleotide-binding domains and transmembrane regions typical of ABC transporters, enabling ATP-dependent substrate translocation. Dysregulation of ABCB8 has been implicated in cardiovascular diseases, diabetes, and cancer, highlighting its importance in cellular metabolism and disease pathogenesis. The ABCB8 antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein expression, localization, and functional alterations in disease models or genetic studies. Its specificity enables researchers to explore ABCB8's interaction with mitochondrial pathways, drug resistance mechanisms, and potential therapeutic targets. Validated antibodies against ABCB8 are essential for advancing research into mitochondrial dysfunction-related disorders and developing strategies to modulate ABC transporter activity in clinical contexts.