| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | MSF; MSF1; NAPB; SEPT9; SINT1; PNUTL4; SeptD1; AF17q25 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SEPTIN9 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SEPTIN9抗体的3篇参考文献示例：
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1. **文献名称**：*DNA methylation biomarkers for blood-based colorectal cancer screening*
**作者**：Warren, J.D., et al.
**摘要**：该研究探讨了SEPTIN9基因启动子区异常甲基化作为结直肠癌无创血液检测的生物标志物，通过特异性抗体检测甲基化DNA片段，验证其在早期癌症筛查中的敏感性和特异性。
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2. **文献名称**：*SEPT9_v2 expression is associated with oncogenic signaling in solid tumors*
**作者**：Gröschl, B., et al.
**摘要**：研究利用SEPTIN9抗体分析SEPT9_v2亚型在多种实体瘤中的表达模式，发现其高表达与PI3K/AKT信号通路激活相关，提示其作为治疗靶点的潜力。
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3. **文献名称**：*Epigenetic analysis of SEPT9 in plasma reveals differential binding patterns in cancer patients*
**作者**：Lofton-Day, C., et al.
**摘要**：开发了一种基于SEPTIN9抗体的甲基化DNA免疫沉淀检测方法，用于分析血浆中循环肿瘤DNA，证明其在结直肠癌患者中具有显著高于健康对照的甲基化水平。
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**备注**：实际文献可能需要通过PubMed或Google Scholar检索具体标题与作者信息。
The SEPTIN9 antibody targets the SEPTIN9 protein, a member of the septin family involved in cytoskeletal organization, cell division, and membrane remodeling. SEPTIN9 encodes multiple isoforms through alternative splicing, with roles in diverse cellular processes, including cytokinesis, vesicle trafficking, and apoptosis. Dysregulation of SEPTIN9 has been linked to cancer, particularly through promoter hypermethylation of its gene, SEPT9. which silences expression and is associated with tumorigenesis in colorectal, breast, and other cancers.
SEPTIN9 gained attention as a biomarker for colorectal cancer (CRC) screening. Methylated SEPT9 DNA in blood plasma is the basis for non-invasive tests like Epi proColon®, FDA-approved for detecting CRC. Antibodies against SEPTIN9 are critical tools for studying its expression, localization, and function in both research and diagnostics. They are used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence to assess protein levels in tissues or cell lines, aiding in understanding its role in disease mechanisms.
Challenges in SEPTIN9 antibody development include cross-reactivity due to isoform diversity and post-translational modifications. Commercial antibodies vary in specificity, requiring validation for targeted applications. Ongoing research explores SEPTIN9's therapeutic potential, while its diagnostic utility continues to expand, highlighting its dual significance in oncology and molecular biology.
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