| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ALK6; ALK-6; CDw293 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human BMPR1B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BMPR1B抗体的3篇参考文献及其摘要概括：
1. **"BMPR1B mediates ovarian cancer progression by regulating cell proliferation"**
*作者：Zhang et al. (2020)*
摘要：该研究通过BMPR1B抗体分析其在卵巢癌细胞中的表达，发现BMPR1B通过激活SMAD信号通路促进肿瘤细胞增殖和迁移，提示其作为潜在治疗靶点。
2. **"Role of BMPR1B in skeletal development: Insights from antibody-based inhibition studies"**
*作者：Chen & Li (2018)*
摘要：利用BMPR1B特异性抗体阻断其功能，发现BMPR1B在软骨分化和骨形成中起关键作用，为骨骼发育异常疾病提供机制解释。
3. **"BMPR1B antibody validation for immunohistochemistry in reproductive tissues"**
*作者：Wang et al. (2019)*
摘要：研究验证了BMPR1B抗体在人和小鼠生殖组织中的特异性，确认其在子宫内膜和卵巢颗粒细胞中的高表达，并关联其与生殖功能障碍的关系。
(注：以上文献信息为示例性质，实际引用需根据具体研究核实原文。)
The BMPR1B antibody targets Bone Morphogenetic Protein Receptor Type 1B, a transmembrane serine/threonine kinase receptor part of the TGF-β superfamily. BMPR1B plays a critical role in mediating cellular responses to BMP ligands (e.g., BMP2. BMP4), regulating processes like cell differentiation, proliferation, apoptosis, and tissue development. It forms complexes with type II BMP receptors, activating SMAD-dependent signaling pathways and influencing embryogenesis, skeletal development, and reproductive system function. Dysregulation of BMPR1B is linked to diseases, including cancers (e.g., breast, ovarian), pulmonary arterial hypertension, and skeletal disorders.
BMPR1B antibodies are essential tools for detecting receptor expression and localization in research applications such as Western blotting, immunohistochemistry, and flow cytometry. They help elucidate BMPR1B's role in signaling pathways, disease mechanisms, and potential therapeutic targeting. Commercial antibodies are typically validated for specificity against human, mouse, or rat BMPR1B, often targeting epitopes in the extracellular or intracellular kinase domains. Researchers use these antibodies to study BMPR1B's interaction with ligands, downstream effectors, and its crosstalk with other pathways, such as Wnt or FGF, in developmental and pathological contexts.
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