Rabbit Polyclonal CHRM1 Antibody

The CHRM1 antibody targets the cholinergic receptor muscarinic 1 (CHRM1), a G protein-coupled receptor (GPCR) that binds acetylcholine. CHRM1 is predominantly expressed in the central nervous system (CNS), smooth muscles, and glands, where it mediates parasympathetic signaling. It plays a critical role in cognitive functions, memory, and regulation of smooth muscle contraction. Dysregulation of CHRM1 is linked to neurological disorders (e.g., Alzheimer’s disease, schizophrenia) and smooth muscle-related conditions (e.g., asthma, overactive bladder). CHRM1 antibodies are essential tools for studying receptor localization, expression levels, and signaling mechanisms in tissues or cell models. They are widely used in techniques like immunohistochemistry (IHC), Western blotting, and flow cytometry. Researchers also employ these antibodies to explore therapeutic strategies, such as developing selective agonists/antagonists for modulating CHRM1 activity. Commercial CHRM1 antibodies are typically raised in rabbits or mice, validated for specificity using knockout controls or blocking peptides. Their applications span neuroscience, pharmacology, and oncology, particularly in understanding receptor dysfunction in diseases or drug responses. Recent studies highlight CHRM1's potential as a biomarker or target in precision medicine, driving interest in high-affinity, isoform-specific antibodies.