| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | CRP1; C/EBP-epsilon |
| WB Predicted band size | 31 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CEBPE |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3条关于CEBPE抗体的模拟参考文献(内容为虚构，仅供示例)：
1. **文献名称**：Role of CEBPE in neutrophil differentiation: antibody-based functional analysis
**作者**：Smith J, et al.
**摘要**：本研究利用特异性CEBPE抗体，通过Western blot和免疫荧光技术，验证了CEBPE蛋白在粒细胞分化过程中的动态表达，并揭示其在调控颗粒酶基因中的关键作用。
2. **文献名称**：CEBPE antibody validation for acute myeloid leukemia (AML) studies
**作者**：Lee H, et al.
**摘要**：通过免疫组化分析AML患者样本，使用高特异性CEBPE抗体证实了CEBPE表达缺失与AML细胞分化阻滞的相关性，为预后评估提供了潜在标志物。
3. **文献名称**：Development of a novel monoclonal antibody against human CEBPE
**作者**：Garcia R, et al.
**摘要**：报道了一种新型CEBPE单克隆抗体的制备与验证，该抗体在流式细胞术和ChIP-seq中表现出高灵敏度，为研究CEBPE的DNA结合功能提供了工具。
(注：以上为模拟内容，实际文献需通过PubMed/Google Scholar等平台检索。)
The CEBPE (CCAAT/Enhancer-Binding Protein Epsilon) antibody is a crucial tool for studying the role of the CEBPE transcription factor in cellular differentiation and immune regulation. CEBPE, a member of the C/EBP family of leucine zipper transcription factors, is predominantly expressed in myeloid cells, particularly during granulocyte maturation. It plays a pivotal role in neutrophil development, regulating genes involved in secondary granule formation, cell cycle arrest, and apoptosis. Dysregulation of CEBPE is linked to congenital neutrophil disorders, such as specific granule deficiency (SGD), characterized by impaired immune function.
CEBPE antibodies are widely used in research applications like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to detect protein expression, localization, and DNA-binding activity. These antibodies help elucidate mechanisms underlying granulopoiesis, inflammation, and hematological malignancies. Commercial CEBPE antibodies are typically raised against specific epitopes (e.g., human CEBPE amino acids 100-250) and validated for specificity across species (human, mouse, rat). Researchers rely on them to investigate CEBPE's interaction with regulatory networks, including its cross-talk with other transcription factors like PU.1 and RUNX1. Their utility extends to clinical studies exploring CEBPE mutations in rare genetic disorders and potential therapeutic targets for blood cancers.
×
