| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | EDS4A |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human COL3A1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于COL3A1抗体的3篇模拟参考文献示例(内容基于领域知识生成，非真实文献，建议通过学术数据库获取真实文献)：
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1. **文献名称**: "COL3A1 Mutations and Vascular Ehlers-Danlos Syndrome: A Comprehensive Genetic Analysis"
**作者**: Pepin MG et al.
**摘要**: 研究通过基因测序分析了COL3A1突变在血管性埃勒斯-当洛斯综合征(vEDS)患者中的分布，并利用特异性抗体进行突变蛋白的免疫组化检测，证实了COL3A1异常表达与血管脆性及组织破裂的相关性。
2. **文献名称**: "Immunohistochemical Localization of Type III Collagen in Human Tissues Using a Novel COL3A1 Antibody"
**作者**: Smith JR et al.
**摘要**: 研究开发了一种高特异性兔源单克隆COL3A1抗体，通过免疫组化验证其在皮肤、血管和肠道等组织中的定位，为III型胶原蛋白在纤维化疾病中的研究提供了可靠工具。
3. **文献名称**: "COL3A1 Overexpression in Cancer-Associated Fibroblasts Promotes Tumor Invasion"
**作者**: Li Y et al.
**摘要**: 利用COL3A1抗体进行Western blot和免疫荧光分析，发现肿瘤微环境中癌相关成纤维细胞(CAFs)的COL3A1高表达与基质重塑和肿瘤转移密切相关，提示其作为治疗靶点的潜力。
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如需真实文献，建议检索PubMed(https://pubmed.ncbi.nlm.nih.gov/)或Google Scholar，使用关键词“COL3A1 antibody”、“type III collagen antibody”结合研究领域(如“fibrosis”“vascular disease”“cancer”)。
The COL3A1 antibody targets the alpha-1 chain of type III collagen, a key fibrillar collagen encoded by the *COL3A1* gene. Type III collagen is a major component of the extracellular matrix (ECM), particularly in tissues requiring elasticity and tensile strength, such as blood vessels, skin, and hollow organs. It forms heterotypic fibrils with type I collagen and plays a critical role in maintaining structural integrity, tissue repair, and embryonic development.
Mutations in *COL3A1* are linked to vascular Ehlers-Danlos syndrome (vEDS), a rare autosomal dominant disorder characterized by fragile blood vessels, organ rupture, and skin hyperextensibility. COL3A1 antibodies are essential tools in research and diagnostics, enabling the detection of type III collagen expression and distribution in tissues via techniques like immunohistochemistry (IHC), immunofluorescence (IF), and Western blot (WB). These antibodies help study ECM remodeling in fibrosis, wound healing, and connective tissue disorders.
In clinical contexts, COL3A1 antibodies aid in confirming vEDS diagnoses by identifying abnormal collagen III production or structure. They also contribute to investigating cardiovascular diseases, fibrosis, and cancer, where collagen III dysregulation is implicated. Recent studies explore their utility in tissue engineering and regenerative medicine, emphasizing the dynamic role of collagen III in cellular signaling and matrix homeostasis.
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