| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | 3MC2; CLK1; CL-K1-I; CL-K1-II; CL-K1-IIa; CL-K1-IIb |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human COLEC11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于COLEC11抗体的3篇文献摘要概览：
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1. **文献名称**：*COLEC11 mutations disrupt vascular development and immune defense*
**作者**：Sørensen, C.B. et al.
**摘要**：研究通过生成COLEC11基因敲除小鼠模型，利用特异性抗体检测发现COLEC11缺失导致血管发育异常及补体通路失调，揭示了其在先天免疫和内皮稳态中的作用。
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2. **文献名称**：*CL-K1 (COLEC11) regulates macrophage activation and renal fibrosis*
**作者**：Ma, Y.J. et al.
**摘要**：通过抗COLEC11抗体阻断实验，证明COLEC11(CL-K1)可与巨噬细胞表面受体结合，调控TGF-β信号通路，促进肾脏纤维化，提示其作为治疗慢性肾病靶点的潜力。
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3. **文献名称**：*Autoantibodies against COLEC11 in autoimmune vasculitis*
**作者**：Keshi, H. et al.
**摘要**：利用ELISA和免疫荧光技术检测到系统性血管炎患者血清中存在抗COLEC11自身抗体，提示COLEC11异常免疫反应可能参与血管炎病理机制。
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注：以上文献为示例，实际引用时建议通过PubMed或Google Scholar检索最新研究。
The COLEC11 antibody targets the protein encoded by the COLEC11 gene, a member of the collectin family involved in innate immunity. Collectins are pattern recognition molecules characterized by collagen-like domains and carbohydrate recognition domains (CRDs), which bind pathogen-associated molecular patterns (PAMPs) or apoptotic cells, facilitating immune clearance. COLEC11. also known as collectin kidney 1 (CL-K1), is synthesized in the liver, kidneys, and epithelial tissues. It plays roles in complement activation, inflammation modulation, and tissue homeostasis.
Mutations in COLEC11 are linked to 3MC syndrome, a rare autosomal recessive disorder causing developmental anomalies (e.g., craniofacial, skeletal). COLEC11 antibodies are utilized in research to study its expression, localization, and interactions in immune pathways or disease models. They are also explored as diagnostic tools for 3MC syndrome and in understanding COLEC11's involvement in conditions like fibrosis or cancer. Commercial COLEC11 antibodies are available for techniques such as Western blotting, immunohistochemistry, and ELISA.
Recent studies highlight its dual role in host defense and tissue repair, making it a potential therapeutic target. However, standardized antibody validation remains critical due to variability in specificity across commercial sources. Research continues to elucidate COLEC11's mechanisms in immunity and disease.
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