Rabbit Polyclonal COL2A1 Antibody

The COL2A1 antibody targets the alpha-1 chain of type II collagen, a critical component of cartilage and other connective tissues. Encoded by the COL2A1 gene, this collagen is essential for the structural integrity and resilience of articular cartilage, vitreous humor, and embryonic skeletal development. It forms heterotypic fibrils with other collagens (e.g., types IX and XI), contributing to tissue strength and flexibility. COL2A1 antibodies are widely used in research to study cartilage development, osteoarthritis, and genetic disorders like Stickler syndrome or chondrodysplasias caused by COL2A1 mutations. These antibodies enable detection of type II collagen in tissues via immunohistochemistry, Western blotting, or immunofluorescence, aiding in the analysis of protein expression, localization, and degradation. In disease models, they help assess cartilage degeneration or repair mechanisms. However, cross-reactivity with denatured collagen epitopes or other collagens (e.g., type XI) may occur, requiring validation using knockout controls or peptide-blocking assays. Clinically, COL2A1 antibodies have potential utility in diagnosing collagenopathies or monitoring cartilage biomarkers in joint diseases. Their specificity and sensitivity make them valuable tools for both basic research and translational studies in musculoskeletal and ocular biology.