| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | VACM1, VACM-1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human CUL5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CUL5抗体的3篇代表性文献示例(注：内容基于模拟数据整理，实际文献需通过学术数据库检索获取)：
1. **文献名称**：*CUL5 regulates HIV-1 replication through modulation of viral core assembly*
**作者**：Zhang M, et al.
**摘要**：该研究利用CUL5特异性抗体，揭示了CUL5蛋白通过泛素化途径参与HIV-1病毒颗粒组装的过程，并证明其与病毒蛋白Vif的相互作用对病毒逃逸宿主限制因子APOBEC3G至关重要。
2. **文献名称**：*Structural basis of CUL5-ElonginB-ElonginC complex assembly in hypoxia signaling*
**作者**：Hansen TM, et al.
**摘要**：通过免疫共沉淀结合冷冻电镜技术(使用CUL5抗体)，解析了CUL5与Elongin B/C复合物的三维结构，阐明了其在缺氧诱导因子(HIF)降解通路中的分子机制。
3. **文献名称**：*CUL5 antibody-based profiling identifies tumor-suppressive roles in colorectal cancer*
**作者**：Chen L, et al.
**摘要**：研究采用CUL5抗体进行组织芯片分析，发现CUL5在结直肠癌中表达下调，并通过泛素化降解致癌蛋白β-catenin发挥抑癌作用，提示其作为潜在治疗靶点。
如需具体文献，建议通过PubMed或Google Scholar搜索关键词“CUL5 antibody” + 研究领域(如“viral infection”“cancer”等)，并筛选近五年高被引论文。
The CUL5 antibody is a research tool designed to detect and study the Cullin 5 (CUL5) protein, a core component of the Cullin-RING E3 ubiquitin ligase (CRL) complexes. CUL5 belongs to the Cullin family of scaffold proteins that play critical roles in the ubiquitin-proteasome system, mediating the targeted degradation of specific substrates through polyubiquitination. CUL5 forms part of the CRL5 complex by interacting with adaptor proteins (e.g., SOCS-box or Elongin BC) and substrate receptors, enabling substrate recognition and recruitment. This complex regulates diverse cellular processes, including cell cycle progression, DNA damage response, and viral defense mechanisms.
CUL5 antibodies are widely used in biomedical research to investigate protein expression, localization, and interactions via techniques like Western blotting, immunoprecipitation, and immunofluorescence. Dysregulation of CUL5 has been implicated in diseases such as cancer, where it may act as a tumor suppressor or promoter depending on context, and in viral infections (e.g., HIV), where viruses exploit CRL5-mediated ubiquitination to evade host immune responses. Researchers also utilize CUL5 antibodies to explore its role in developmental disorders and neurodegenerative conditions linked to ubiquitin system dysfunction. The specificity and sensitivity of these antibodies are critical for elucidating CUL5's molecular mechanisms and therapeutic potential.
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