| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | PTX1 |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CRP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于C-反应蛋白(CRP)抗体的3篇参考文献示例(文献信息为示例，非真实存在)：
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1. **文献名称**: *Monoclonal Antibodies Against C-Reactive Protein: Development and Clinical Applications*
**作者**: Smith A, et al.
**摘要**: 本研究报道了针对CRP表位的高亲和力单克隆抗体的开发，验证了其在ELISA和免疫组化中的灵敏度和特异性，并探讨其在炎症性疾病诊断中的潜在应用。
2. **文献名称**: *CRP as a Biomarker in Cardiovascular Diseases: Role of Anti-CRP Antibodies*
**作者**: Johnson R, et al.
**摘要**: 通过分析CRP抗体在动脉粥样硬化患者血清中的结合能力，揭示了CRP与心血管疾病风险的关联，提出抗CRP抗体可能用于风险评估或靶向治疗。
3. **文献名称**: *Anti-CRP Autoantibodies in Autoimmune Disorders: Mechanisms and Implications*
**作者**: Lee S, et al.
**摘要**: 研究发现类风湿关节炎患者体内存在抗CRP自身抗体，可能通过干扰CRP的免疫调节功能加剧炎症反应，为自身免疫疾病的机制研究提供了新视角。
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注：以上文献为示例，实际引用时请通过学术数据库(如PubMed、Web of Science)检索真实文献。
C-reactive protein (CRP) antibodies are immunological tools designed to detect and quantify CRP, a key acute-phase protein synthesized by the liver in response to inflammation, infection, or tissue injury. Discovered in 1930. CRP binds to phosphocholine on pathogens and damaged cells, activating the complement system and promoting phagocytosis, making it a critical component of innate immunity. Structurally, CRP is a pentameric molecule belonging to the pentraxin family.
CRP antibodies, typically monoclonal or polyclonal, are generated by immunizing animals with purified CRP. These antibodies enable precise measurement of CRP levels in clinical and research settings. Elevated CRP concentrations correlate with conditions like bacterial infections, autoimmune diseases (e.g., rheumatoid arthritis), and cardiovascular diseases. High-sensitivity CRP (hs-CRP) assays, using specific antibodies, help assess low-grade inflammation linked to atherosclerosis and predict cardiovascular risk.
In diagnostics, CRP antibody-based assays (e.g., ELISA, immunoturbidimetry) are standard for monitoring disease activity and treatment response. Research applications include studying CRP's role in inflammatory pathways and its potential as a therapeutic target. Challenges remain in ensuring antibody specificity, as CRP shares structural homology with other pentraxins. Nonetheless, CRP antibodies remain indispensable in understanding and managing inflammation-related disorders.
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