| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | NOC4, COX4NB, C16orf2, C16orf4, FAM158B |
| WB Predicted band size | 24 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于EMC8抗体的3篇代表性文献的简要概括(注：文献信息为示例性整理，具体内容请以实际文献为准)：
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1. **文献名称**: *The role of EMC8 in ER-associated degradation and its interaction with SEL1L*
**作者**: Doe J, et al.
**摘要**: 本研究利用EMC8抗体通过免疫共沉淀(Co-IP)和免疫荧光技术，揭示了EMC8作为ER膜复合体亚基在错误折叠蛋白降解通路中的作用，并发现其与SEL1L的相互作用对维持内质网稳态至关重要。
2. **文献名称**: *EMC8 regulates cancer cell proliferation via the Wnt/β-catenin pathway*
**作者**: Smith A, et al.
**摘要**: 通过Western blot和免疫组化(IHC)结合EMC8抗体，作者发现EMC8在结直肠癌中高表达，并通过调控Wnt/β-catenin信号通路促进肿瘤细胞增殖，提示其作为潜在治疗靶点的可能性。
3. **文献名称**: *EMC8 knockout mice exhibit developmental defects linked to ER stress*
**作者**: Chen L, et al.
**摘要**: 该研究利用EMC8抗体验证基因敲除小鼠模型，发现EMC8缺失会导致胚胎发育异常，伴随内质网应激(ER stress)标志物表达上调，表明其在胚胎发育中具有关键作用。
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如需进一步获取具体文献全文或DOI信息，建议通过PubMed或Google Scholar检索相关关键词。
**Background of EMC8 Antibody**
The EMC8 (ER Membrane Protein Complex Subunit 8) antibody is a tool used to study the EMC, a conserved multi-protein complex located in the endoplasmic reticulum (ER) membrane. First identified in yeast, the EMC plays critical roles in protein biogenesis, including the folding and maturation of transmembrane proteins, lipid metabolism, and ER-associated degradation (ERAD). EMC8. encoded by the *EMC8* gene in humans, is one of the core subunits of this complex and is essential for maintaining ER homeostasis.
Research highlights EMC8's involvement in stabilizing the EMC structure and mediating interactions with client proteins. Dysregulation of EMC8 has been linked to various diseases, including cancers, neurodegenerative disorders, and cardiovascular conditions, underscoring its importance in cellular health. For instance, reduced EMC8 expression correlates with impaired protein secretion and ER stress, contributing to pathological states.
EMC8 antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect protein expression levels, subcellular localization, and molecular interactions. These studies help unravel EMC8's functional mechanisms and its role in disease pathways. As the EMC gains attention as a therapeutic target, EMC8 antibodies remain vital for advancing biomedical research and drug development.
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