| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | 3M1; KIAA0076; dJ20C7.5 |
| WB Predicted band size | 191 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Fusion protein of human CUL7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CUL7抗体的3篇参考文献示例(内容为模拟虚构，仅供参考)：
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1. **文献名称**: *CUL7 Antibody Characterization and Its Role in 3M Syndrome Diagnosis*
**作者**: Yoshida K, et al.
**摘要**: 本研究验证了一种特异性识别CUL7蛋白的单克隆抗体，并探讨其在3M综合征(一种与CUL7基因突变相关的遗传病)临床诊断中的应用。通过免疫印迹和免疫组化实验，证明该抗体能有效区分患者与健康个体的组织样本。
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2. **文献名称**: *CUL7-P53 Interaction in Tumor Suppression: Insights from Antibody-Based Inhibition Studies*
**作者**: Huber M, et al.
**摘要**: 利用CUL7抗体阻断CUL7与p53的相互作用，发现CUL7通过调控p53泛素化影响肿瘤细胞凋亡。研究提示CUL7抗体可作为探究癌症中蛋白降解通路的重要工具。
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3. **文献名称**: *Development of a High-Affinity CUL7 Antibody for Functional Proteomics Analysis*
**作者**: Zhang L, et al.
**摘要**: 报道一种高亲和力兔源多克隆抗体的制备，结合质谱分析揭示CUL7在细胞周期调控中的蛋白互作网络，为研究CUL7复合物的分子机制提供新资源。
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如需真实文献，建议在PubMed或Google Scholar以“CUL7 antibody”为关键词检索。
CUL7 (Cullin 7) is a member of the Cullin protein family, which plays a critical role in the ubiquitin-proteasome system by serving as scaffolds for E3 ubiquitin ligase complexes. Structurally, CUL7 contains a Cullin homology domain, a ROC1-binding domain, and a unique C-terminal region that interacts with adaptor proteins like SKP1 and the F-box protein FBXW8. This assembly facilitates substrate recognition and ubiquitination, targeting specific proteins for degradation. CUL7 is notably involved in cellular processes such as cell cycle regulation, DNA damage response, and cytoskeletal organization.
Mutations in the CUL7 gene are linked to 3M syndrome, a rare genetic disorder characterized by growth retardation, skeletal abnormalities, and facial dysmorphism. Additionally, CUL7 has been implicated in cancer biology. Overexpression of CUL7 is observed in certain malignancies, including breast and lung cancers, where it may promote tumorigenesis by stabilizing oncoproteins or inhibiting tumor suppressors. Conversely, its downregulation has been associated with chemoresistance in some contexts.
CUL7 antibodies are essential tools for studying these biological and pathological mechanisms. They enable the detection of CUL7 expression levels, post-translational modifications, and interactions with binding partners in techniques like Western blotting, immunoprecipitation, and immunohistochemistry. Researchers also use these antibodies to explore CUL7's role in disease models, aiding in the development of targeted therapies for cancers or genetic disorders linked to CUL7 dysfunction.
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