| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CX40; ATFB11 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human GJA5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GJA5抗体的3篇模拟参考文献示例(内容基于典型研究方向概括，非真实文献)：
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1. **标题**: *GJA5 (Connexin 40) Antibody Localization in Atrial Fibrillation Patients*
**作者**: Smith A, et al.
**摘要**: 研究通过免疫组化分析房颤患者心脏组织中GJA5蛋白的表达及分布，发现GJA5抗体检测到的心房连接蛋白表达降低与电传导异常相关。
2. **标题**: *Role of GJA5 in Vascular Development: Insights from Antibody-Based Knockdown Models*
**作者**: Chen L, et al.
**摘要**: 利用GJA5抗体阻断内皮细胞中Connexin 40的功能，发现其参与血管形成调控，抗体特异性验证支持其在体内模型中的信号通路研究。
3. **标题**: *Autoantibodies Against GJA5 in Idiopathic Cardiomyopathy*
**作者**: Tanaka K, et al.
**摘要**: 报道在特发性心肌病患者血清中发现抗GJA5自身抗体，提示这类抗体可能通过干扰细胞间连接加重心肌电活动紊乱。
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**提示**：以上为模拟示例，实际文献需通过PubMed、Web of Science等平台检索关键词“GJA5 antibody”或“Connexin 40 antibody”获取。
The GJA5 antibody targets the Gap Junction Alpha-5 protein, also known as Connexin 40 (Cx40), a member of the connexin family. Connexins form gap junctions, intercellular channels that facilitate direct communication between adjacent cells by allowing the passage of small molecules, ions, and electrical signals. GJA5/Cx40 is predominantly expressed in the cardiovascular system, including atrial cardiomyocytes, vascular endothelial cells, and smooth muscle cells. It plays a critical role in maintaining synchronized electrical activity in the heart, particularly in atrial conduction, and regulates vascular tone.
Antibodies against GJA5 are widely used in research to study its expression, localization, and function in normal and pathological conditions. For example, altered GJA5 expression has been linked to atrial fibrillation, congenital heart defects, and hypertension. Researchers employ these antibodies in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize Cx40 distribution in tissues or assess its protein levels. Additionally, GJA5 antibodies aid in exploring the molecular mechanisms of gap junction remodeling in disease models, offering insights into potential therapeutic targets. Their specificity and reliability are crucial for distinguishing Cx40 from other connexin isoforms, such as Cx43 or Cx37. which share structural similarities but differ in tissue distribution and function.
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