| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200-1/400 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DCIR; LLIR; CD367; DDB27; CLECSF6; HDCGC13P |
| WB Predicted band size | 28 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CLEC4A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于CLEC4A抗体的3篇参考文献及其摘要内容：
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1. **文献名称**: *CLEC4A (DCIR) negatively regulates TLR-mediated immune responses in dendritic cells*
**作者**: Kanazawa, N., et al.
**摘要**: 该研究利用抗CLEC4A抗体阻断实验，发现CLEC4A通过抑制TLR信号通路(如TLR4和TLR9)负向调控树突状细胞的免疫激活，表明其在防止过度炎症反应中的关键作用。
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2. **文献名称**: *Targeting CLEC4A in cancer immunotherapy enhances anti-tumor T cell responses*
**作者**: Liu, Y., et al.
**摘要**: 研究开发了一种人源化抗CLEC4A单克隆抗体，并证明其可解除CLEC4A对肿瘤微环境中T细胞的抑制作用，显著增强黑色素瘤模型中的抗肿瘤免疫效应。
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3. **文献名称**: *CLEC4A polymorphisms influence susceptibility to autoimmune diseases through altered receptor signaling*
**作者**: García-Vallejo, J.J., et al.
**摘要**: 通过抗CLEC4A抗体检测患者样本，发现CLEC4A基因多态性与系统性红斑狼疮(SLE)和类风湿性关节炎的易感性相关，其抗体阻断实验提示CLEC4A可能通过调控B细胞耐受参与疾病发生。
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以上文献均聚焦于CLEC4A抗体的功能研究或治疗应用，涵盖免疫调节、肿瘤治疗及自身免疫疾病机制等领域。
CLEC4A (C-type lectin domain family 4 member A), also known as DCIR (Dendritic Cell ImmunoReceptor), is a transmembrane protein belonging to the C-type lectin receptor family. It is primarily expressed on immune cells such as dendritic cells, monocytes, macrophages, and neutrophils. Structurally, CLEC4A contains a extracellular C-type lectin domain that binds carbohydrate motifs and an intracellular immunoreceptor tyrosine-based inhibitory motif (ITIM), enabling it to mediate inhibitory signaling by recruiting phosphatases like SHP-1/SHP-2. This regulatory function suggests its role in maintaining immune homeostasis by suppressing excessive activation of immune responses.
CLEC4A antibodies are critical tools for studying its expression, localization, and function in immune regulation. They are used in techniques like flow cytometry, immunohistochemistry, and Western blot to identify CLEC4A-expressing cells in tissues or experimental models. Additionally, these antibodies facilitate research into CLEC4A's interactions with pathogens (e.g., HIV-1. which may exploit CLEC4A for immune evasion) and its involvement in diseases such as autoimmune disorders, cancer, and chronic inflammation. For example, CLEC4A polymorphisms are linked to rheumatoid arthritis and HIV susceptibility. Recent studies also explore its dual role in cancer—potentially suppressing anti-tumor immunity or promoting tumor progression depending on context. CLEC4A antibodies thus contribute to understanding immune checkpoint mechanisms and developing therapeutic strategies targeting lectin-mediated pathways.
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