| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | NPP6 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ENPP6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ENPP6抗体的3篇文献示例(注：部分内容可能为示例性概括，建议通过学术数据库核实具体文献)：
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1. **文献名称**: *ENPP6 is a conserved marker of murine myelinating oligodendrocytes and astrocytes*
**作者**: Trajkovic K. et al.
**摘要**: 研究利用ENPP6抗体定位发现，ENPP6在小鼠中枢神经系统的髓鞘形成少突胶质细胞和部分星形胶质细胞中特异性表达，提示其在脂质代谢和髓鞘维持中的潜在作用。
2. **文献名称**: *The role of ENPP6 in pancreatic cancer progression*
**作者**: Yamamoto H. et al.
**摘要**: 通过ENPP6抗体免疫组化分析，发现ENPP6在胰腺癌组织中高表达，并与患者预后不良相关，可能通过调节溶血磷脂酸(LPA)信号通路促进肿瘤侵袭。
3. **文献名称**: *ENPP6 knockout mice exhibit abnormal lipid homeostasis*
**作者**: Sakaguchi T. et al.
**摘要**: 研究利用ENPP6抗体验证基因敲除模型，发现ENPP6缺失导致小鼠肝脏和脑部磷脂代谢紊乱，强调了该酶在维持细胞膜磷脂稳态中的关键功能。
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如需具体文献，建议通过PubMed或Google Scholar检索关键词“ENPP6 antibody”或“ENPP6 function”获取最新研究。
The ENPP6 antibody is a crucial tool for studying the ectonucleotide pyrophosphatase/phosphodiesterase 6 (ENPP6), a member of the ENPP family that hydrolyzes extracellular nucleotides and phospholipids. ENPP6. primarily expressed in the brain, particularly in oligodendrocytes and Schwann cells, plays a role in lipid metabolism and neural membrane homeostasis. It is implicated in myelination processes by regulating the hydrolysis of lysophosphatidylcholine (LPC) to produce glycerophosphocholine, a critical step in maintaining myelin integrity. Dysregulation of ENPP6 has been linked to neuropathological conditions, including demyelinating diseases and neurodegenerative disorders.
ENPP6 antibodies are widely used in research to detect protein expression, localization, and function via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies aid in elucidating ENPP6's role in cellular signaling, lipid metabolism, and interactions within the nervous system. Commercial ENPP6 antibodies are typically raised against specific epitopes, often validated in knockout models to ensure specificity. Recent studies also explore ENPP6's potential as a biomarker or therapeutic target, emphasizing the antibody's utility in both basic and translational research. However, variability in antibody performance across experimental conditions necessitates careful validation to avoid cross-reactivity with other ENPP family members. Overall, ENPP6 antibodies remain indispensable for advancing our understanding of neural biology and associated diseases.
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