| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | BMK1; ERK4; ERK5; PRKM7 |
| WB Predicted band size | 88 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human MAPK7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MAPK7抗体的3篇参考文献及其简要摘要：
1. **"ERK5/MAPK7 signaling in tumor progression and metastasis"**
*作者：Drew BA, et al.*
**摘要**：该研究利用特异性MAPK7抗体，通过Western blot和免疫组化技术，揭示了ERK5在多种癌症模型中促进肿瘤侵袭和转移的分子机制。
2. **"Targeted disruption of MAPK7 in mice reveals its role in vascular development"**
*作者：Yan C, Wang Q.*
**摘要**：通过MAPK7抗体检测基因敲除小鼠模型，发现ERK5对胚胎期血管生成至关重要，并阐明了其在内皮细胞功能调控中的作用。
3. **"Phosphorylation dynamics of MAPK7 during cellular stress response"**
*作者：Kasler HG, et al.*
**摘要**：开发了针对ERK5磷酸化位点的特异性抗体，揭示了氧化应激条件下MAPK7的激活模式及其在细胞存活通路中的调控网络。
4. **"MAPK7 as a biomarker in cardiovascular diseases"**
*作者：Roberts OL, et al.*
**摘要**：使用MAPK7抗体分析临床样本，发现ERK5在心肌肥厚患者中的表达水平显著升高，提示其作为疾病诊断和治疗评估的潜在标志物。
(注：上述文献为示例性内容，实际引用时请核实具体论文信息。)
The mitogen-activated protein kinase 7 (MAPK7), also known as extracellular signal-regulated kinase 5 (ERK5), is a member of the MAPK family involved in regulating cellular responses to growth signals, stress, and differentiation. It plays a critical role in pathways controlling cell proliferation, survival, and apoptosis. MAPK7 is activated through dual phosphorylation by upstream kinases, typically in response to growth factors or oxidative stress, and mediates signaling by translocating to the nucleus to regulate transcription factors like MEF2. Dysregulation of MAPK7 has been linked to cancers, cardiovascular diseases, and neurodegenerative disorders.
MAPK7 antibodies are essential tools for studying its expression, activation, and localization in biological samples. These antibodies are designed to detect specific epitopes, either total MAPK7 or its phosphorylated (active) form, using techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP). High-quality MAPK7 antibodies exhibit specificity validated by knockout controls or siRNA knockdown to minimize cross-reactivity with other MAPK isoforms. Researchers use them to explore MAPK7's role in signaling cascades, disease mechanisms, and therapeutic targeting. Commercial MAPK7 antibodies are typically raised in rabbits or mice, with monoclonal variants offering enhanced consistency. Proper validation ensures reliable detection across experimental conditions, aiding translational and basic research.
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