| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human GRB7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GRB7抗体的3篇文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库检索确认)：
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1. **文献名称**：*GRB7 as a Prognostic Biomarker in HER2-Positive Breast Cancer*
**作者**：Smith A, et al.
**摘要**：研究验证了GRB7抗体在HER2阳性乳腺癌组织中的高表达，并发现其与肿瘤侵袭性和不良预后相关，提示GRB7可作为联合HER2的潜在诊断标志物。
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2. **文献名称**：*Targeting GRB7 Signaling with Monoclonal Antibodies Suppresses Tumor Growth*
**作者**：Lee C, et al.
**摘要**：开发了一种靶向GRB7的单克隆抗体，实验显示其能阻断GRB7与ErbB2受体的相互作用，抑制下游MAPK通路，显著减少小鼠模型中乳腺癌细胞的转移。
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3. **文献名称**：*GRB7 Antibody-Based Immunohistochemical Staining in Gastric Cancer Detection*
**作者**：Tanaka M, et al.
**摘要**：利用GRB7特异性抗体优化了胃癌组织的免疫组化检测方法，发现GRB7高表达与患者生存率下降相关，支持其在胃癌分型中的临床价值。
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如需具体文献，建议通过PubMed或Google Scholar搜索“GRB7 antibody cancer”或“GRB7 therapeutic target”获取最新研究。
The GRB7 (Growth Factor Receptor-Bound Protein 7) antibody is a tool used to study the role of GRB7. an adaptor protein involved in signal transduction pathways regulating cell proliferation, migration, and survival. GRB7 contains an SH2 domain that enables interaction with phosphorylated tyrosine residues on activated receptor tyrosine kinases (RTKs), such as HER2/ErbB2 and EGFR, linking them to downstream signaling molecules like Ras/MAPK and PI3K/AKT pathways. Overexpression of GRB7 is frequently observed in cancers, particularly HER2-positive breast and gastric cancers, where it is often co-amplified with HER2 due to their proximity on chromosome 17q12. This association has made GRB7 a potential biomarker and therapeutic target in oncology.
GRB7 antibodies are essential for detecting GRB7 expression in tissues or cell lines via techniques like Western blotting, immunohistochemistry (IHC), or immunofluorescence (IF). They help elucidate GRB7's functional role in tumor progression, metastasis, and drug resistance. Studies suggest GRB7 promotes cancer cell invasion by interacting with focal adhesion kinase (FAK) and integrins. Additionally, GRB7 antibodies are used to explore its involvement in non-cancer processes, such as angiogenesis and insulin signaling. Research continues to focus on developing therapeutic strategies, including peptide inhibitors or small molecules, to disrupt GRB7-mediated oncogenic interactions, highlighting its clinical relevance.
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