| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DRM; HMPS; MPSH; PIG2; CRAC1; CRCS4; DAND2; HMPS1; IHG-2; DUP15q; C15DUPq; GREMLIN; CKTSF1B1 |
| WB Predicted band size | 21 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human GREM1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GREM1抗体的3篇参考文献示例(注：文献为虚构示例，实际引用需核实)：
1. **文献名称**：*GREM1 Antibody Blocks BMP Signaling and Attenuates Cancer Metastasis*
**作者**：Smith A, et al.
**摘要**：研究开发了一种特异性GREM1单克隆抗体，通过抑制GREM1与BMP的相互作用，阻断下游信号通路，显著降低多种癌症模型中的肿瘤转移能力。
2. **文献名称**：*Targeting GREM1 in Pulmonary Fibrosis: A Therapeutic Antibody Approach*
**作者**：Chen L, et al.
**摘要**：该文献报道了一种人源化GREM1抗体，在肺纤维化小鼠模型中可中和GREM1的活性，减少胶原沉积并改善肺功能，提示其作为纤维化疾病治疗的潜力。
3. **文献名称**：*GREM1 Expression Profiling in Colorectal Cancer Using a Novel Immunohistochemical Antibody*
**作者**：Wang Y, et al.
**摘要**：研究验证了一种高灵敏度GREM1抗体的临床应用，通过免疫组化分析结直肠癌组织，发现GREM1高表达与患者预后不良显著相关。
如需真实文献，建议通过PubMed或Google Scholar以关键词“GREM1 antibody”、“GREM1 therapeutic targeting”检索近期研究。
The GREM1 (Gremlin 1) antibody is a tool used to detect and study the GREM1 protein, a member of the cysteine knot superfamily. GREM1 is a secreted glycoprotein best known as a bone morphogenetic protein (BMP) antagonist. It binds to BMP ligands, inhibiting their interaction with receptors and thereby modulating BMP signaling pathways critical for embryonic development, tissue homeostasis, and cellular differentiation. Dysregulation of GREM1 has been implicated in various pathological conditions, including cancer, fibrosis, and metabolic disorders. In oncology, elevated GREM1 expression is associated with tumor progression, metastasis, and resistance to therapy in cancers such as colorectal, pancreatic, and breast cancer. Its role in fibrosis involves promoting fibroblast activation and extracellular matrix deposition.
The GREM1 antibody is widely utilized in research to investigate these mechanisms. Applications include immunohistochemistry (IHC), Western blotting, and ELISA to assess protein expression levels, localization, and interactions in tissues or cell lines. Commercially available antibodies are typically validated for specificity and sensitivity, though performance may vary depending on epitope targets (e.g., N-terminal vs. C-terminal regions). Recent studies also explore GREM1 as a potential biomarker or therapeutic target, driving demand for reliable detection tools. However, conflicting findings about its pro- or anti-tumorigenic roles in certain contexts highlight the need for further research, underscoring the antibody's importance in elucidating GREM1's complex biological functions.
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