Rabbit Polyclonal SCARB1 Antibody

The scavenger receptor class B type 1 (SCARB1), also known as SR-BI, is a cell surface glycoprotein that plays a critical role in cholesterol metabolism, particularly in mediating the selective uptake of high-density lipoprotein (HDL)-derived cholesteryl esters into cells. SCARB1 antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts. These antibodies are widely used in research to investigate lipid transport mechanisms, atherosclerosis, cardiovascular diseases, and metabolic disorders such as diabetes. SCARB1 is highly expressed in liver, adrenal glands, and reproductive tissues, where it regulates reverse cholesterol transport and steroidogenesis. Additionally, SCARB1 serves as a receptor for hepatitis C virus (HCV) entry, making its antibodies relevant in virology studies. Researchers employ SCARB1 antibodies in techniques like Western blotting, immunohistochemistry, flow cytometry, and immunofluorescence to assess protein levels, tissue distribution, and cellular trafficking. Monoclonal and polyclonal variants are available, often targeting specific epitopes within its large extracellular domain or C-terminal cytoplasmic region. Dysregulation of SCARB1 is linked to altered HDL metabolism, inflammation, and cancer progression, highlighting its therapeutic potential. Studies using SCARB1 knockout models and antibody-based inhibition have further elucidated its role in lipid homeostasis and disease pathways, driving interest in drug development targeting this receptor.