| WB | 1/1000-1/5000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | FPS |
| Entrez GeneID | 2242 |
| clone | 2E3G3 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of FES (AA:613-822)expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是关于GSR(谷胱甘肽还原酶)抗体的3篇参考文献示例(文献信息为模拟概括，建议通过学术数据库验证具体内容)：
1. **"Antibody-based detection of glutathione reductase in neurodegenerative disease models"**
- 作者：Becker, K., et al.
- 摘要：研究通过Western blot和免疫组化技术，使用特异性GSR抗体检测帕金森病小鼠模型中谷胱甘肽还原酶的表达变化，发现其活性降低与氧化应激水平升高相关。
2. **"Development of a monoclonal antibody for human glutathione reductase: applications in clinical diagnostics"**
- 作者：Holmgren, A., & Lu, J.
- 摘要：报道一种高特异性抗人GSR单克隆抗体的开发，验证其在血清和细胞裂解液中的检测灵敏度，并探讨其在氧化应激相关疾病(如糖尿病)诊断中的潜在价值。
3. **"Localization of glutathione reductase in plant and mammalian cells using immunofluorescence microscopy"**
- 作者：Deponte, M., et al.
- 摘要：利用GSR抗体进行亚细胞定位研究，揭示该酶在线粒体和细胞质中的分布差异，并比较植物与哺乳动物细胞中GSR功能的进化保守性。
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**注**：以上文献名为示例性概括，实际文献需通过PubMed、Google Scholar等平台检索关键词(如"glutathione reductase antibody" + "application")。如需具体文献，可提供更详细的研究背景或目标。
**Background of GSR Antibody**
Glutathione reductase (GSR) is a critical enzyme in the cellular antioxidant defense system, responsible for maintaining reduced glutathione (GSH), a vital molecule that neutralizes reactive oxygen species (ROS) and mitigates oxidative stress. GSR catalyzes the reduction of oxidized glutathione (GSSG) to GSH using NADPH as a cofactor, ensuring the redox balance essential for cellular homeostasis. Dysregulation of GSR activity or expression is linked to various pathologies, including neurodegenerative disorders, cancer, and cardiovascular diseases, highlighting its role in oxidative stress-related mechanisms.
GSR antibodies are immunological tools designed to detect, quantify, and study the expression, localization, and function of GSR in biological samples. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to investigate GSR's involvement in disease pathways or therapeutic responses. For instance, reduced GSR levels have been observed in aging tissues and certain cancers, making it a potential biomarker or therapeutic target.
Commercially available GSR antibodies are often generated against specific epitopes of human or other species' GSR proteins, with validation for specificity and sensitivity across applications. Researchers utilize these antibodies to explore antioxidant defense mechanisms, evaluate drug efficacy in preclinical models, or diagnose oxidative stress-related conditions. As interest in redox biology grows, GSR antibodies remain indispensable for elucidating the enzyme's role in health and disease, bridging basic research and clinical applications.
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