| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CANP; muCL; CANP1; SPG76; CANPL1; muCANP |
| Entrez GeneID | 823 |
| clone | 1E6G9 |
| WB Predicted band size | 81.9kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human CAPN1 (AA: 501-714) expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide |
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以下是3-4篇关于INHBA抗体的参考文献示例(内容为模拟，仅供参考)：
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1. **文献名称**：*INHBA Expression in Colorectal Cancer: Prognostic and Therapeutic Implications*
**作者**：Smith J, et al.
**摘要**：通过免疫组化(使用INHBA特异性抗体)分析结直肠癌组织中INHBA蛋白表达水平，发现其高表达与患者不良预后相关，并提示INHBA可能作为潜在治疗靶点。
2. **文献名称**：*Role of Activin A (INHBA) in Pulmonary Fibrosis*
**作者**：Lee H, et al.
**摘要**：利用INHBA抗体检测肺纤维化小鼠模型中激活素A的表达，证实INHBA通过TGF-β通路促进成纤维细胞活化，为抗纤维化药物开发提供依据。
3. **文献名称**：*INHBA Antibody-Based Detection in Ovarian Granulosa Cell Tumors*
**作者**：Chen R, et al.
**摘要**：研究使用INHBA单克隆抗体对卵巢颗粒细胞瘤进行Western blot和免疫荧光分析，发现INHBA异常表达与肿瘤激素分泌失调密切相关。
4. **文献名称**：*Multi-Cancer Analysis of INHBA via Immunohistochemical Staining*
**作者**：Wang Y, et al.
**摘要**：基于INHBA抗体的多癌种组织芯片分析显示，INHBA在胃癌、胰腺癌中显著高表达，且与转移和化疗耐药性相关，提示其作为泛癌标志物的潜力。
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注：以上文献为示例，实际引用需根据具体研究补充真实来源(可通过PubMed、Google Scholar等平台搜索关键词“INHBA antibody”或“INHBA immunohistochemistry”获取)。
INHBA (Inhibin Beta A) is a subunit of the glycoprotein hormone inhibin and activin, belonging to the transforming growth factor-beta (TGF-β) superfamily. The INHBA gene encodes the beta A subunit, which combines with alpha subunits to form inhibin or with other beta subunits (e.g., beta B) to form activin ligands. Activins, particularly activin A (βA-βA homodimer), regulate diverse biological processes, including cell proliferation, differentiation, apoptosis, and immune responses, by signaling through transmembrane serine/threonine kinase receptors (ActRII/ALK) and SMAD-mediated pathways. Dysregulation of INHBA/activin signaling is implicated in cancer progression, fibrosis, and reproductive disorders.
INHBA antibodies are essential tools for detecting and quantifying INHBA protein expression in research and diagnostics. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and ELISA to study INHBA's role in developmental biology, tissue homeostasis, and diseases. Overexpression of INHBA has been linked to poor prognosis in cancers such as gastric, colorectal, and ovarian cancers, making it a potential biomarker or therapeutic target. These antibodies also aid in exploring activin/inhibin balance in reproductive health, including folliculogenesis and steroidogenesis. Commercial INHBA antibodies are typically validated for specificity against recombinant or endogenous targets, ensuring reliability in experimental and clinical applications.
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