| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | 3MC1; MAP1; MASP; RaRF; CRARF; MASP3; MAp44; PRSS5; CRARF1 |
| WB Predicted band size | 79 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human MASP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇关于MASP1抗体的代表性文献摘要(信息经简化处理)：
1. **标题**：Monoclonal Antibodies against MASP-1 of the Lectin Complement Pathway
**作者**：Takahashi M et al.
**摘要**：研究报道了针对人MASP1蛋白的单克隆抗体制备，验证了其特异性结合能力，并证明该抗体能够有效抑制凝集素途径补体激活，为研究MASP1功能提供了工具。
2. **标题**：Targeting MASP-1/3-mediated complement activation inhibits endometrial inflammation in recurrent implantation failure
**作者**：Chen J et al.
**摘要**：通过开发靶向MASP1/3的小分子抗体，发现其可减少补体介导的子宫内膜炎症反应，提出该抗体在治疗复发性着床失败中的潜在应用价值。
3. **标题**：Structural basis of MASP-1/3 interaction with C4-inhibitory antibodies
**作者**：Gál P et al.
**摘要**：利用冷冻电镜解析了MASP1/3复合体与抑制性抗体的结合位点，揭示了抗体通过阻断酶活性结构域发挥补体抑制作用的分子机制。
注：文献标题和作者为示例性虚构内容(真实文献需通过PubMed等数据库检索)，建议使用关键词"MASP1 antibody"在PubMed Central或Web of Science获取最新研究原文。
The MASP1 (Mannan-Binding Lectin Serine Protease 1) antibody targets a key enzyme in the lectin pathway of the complement system. MASP1 is synthesized primarily in the liver and circulates as a zymogen bound to pattern-recognition molecules like MBL (mannose-binding lectin), ficolins, and collectins. Upon pathogen-associated molecular pattern recognition, MASP1 undergoes autoactivation, playing a dual role: it cleaves complement components C4 and C2 to initiate the complement cascade, and exhibits thrombin-like activity, contributing to coagulation and inflammatory responses.
MASP1 antibodies are essential tools for studying its expression, activation mechanisms, and interactions in immune regulation. Dysregulation of MASP1 is linked to diseases, including 3MC syndrome (a developmental disorder caused by genetic mutations) and inflammatory or autoimmune conditions. Research applications include immunohistochemistry, Western blotting, and functional assays to explore its role in host defense, immune-complex disorders, and potential therapeutic targeting. Commercial antibodies are typically raised against specific epitopes of human MASP1. enabling isoform-specific detection given its structural homology with MASP2 and MAp44. Recent studies also investigate its non-complement functions in embryogenesis and tissue remodeling.
×
