| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | Mis5; P105MCM; MCG40308 |
| WB Predicted band size | 93 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human MCM6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与MCM6抗体相关的示例文献(内容为虚构，仅供参考格式)：
1. **文献名称**: *MCM6 as a Proliferation Marker in Colorectal Cancer: Immunohistochemical Analysis*
**作者**: Smith A, et al. (2021)
**摘要**: 研究通过免疫组化分析MCM6抗体在结直肠癌组织中的表达，发现其与Ki-67标记指数高度相关，表明MCM6可作为评估肿瘤增殖活性的可靠标志物。
2. **文献名称**: *Diagnostic Utility of MCM6 Antibody in Pancreatic Neuroendocrine Tumors*
**作者**: Lee H, et al. (2019)
**摘要**: 比较MCM6抗体与其他增殖标记物(如Ki-67)在胰腺神经内分泌肿瘤中的诊断效能，证实MCM6在区分低级别与高级别肿瘤中具有更高敏感性。
3. **文献名称**: *MCM6 Overexpression in Hepatocellular Carcinoma: Correlation with Clinical Prognosis*
**作者**: Wang X, et al. (2020)
**摘要**: 利用MCM6抗体检测肝细胞癌患者组织样本，发现MCM6高表达与患者总生存期缩短显著相关，提示其作为独立预后因子的潜力。
**注**: 实际文献需通过PubMed/Web of Science等平台检索，建议结合关键词“MCM6 antibody”+“biomarker”/“cancer”筛选近年研究。
The MCM6 antibody is a crucial tool in molecular biology for studying the Minichromosome Maintenance Complex Component 6 (MCM6), a member of the MCM protein family. MCM proteins are essential for DNA replication, acting as part of the replication licensing complex that ensures DNA is copied only once per cell cycle, maintaining genomic stability. MCM6. along with MCM2-7. forms a hexameric helicase complex critical for initiating DNA replication by unwinding double-stranded DNA at replication origins.
MCM6 antibodies are widely used in research to detect MCM6 expression and localization, employing techniques like Western blotting, immunofluorescence, and immunohistochemistry. These antibodies help investigate cell proliferation dynamics, as MCM6 is overexpressed in actively dividing cells, making it a biomarker for cellular proliferation. In cancer research, elevated MCM6 levels correlate with tumor aggressiveness and poor prognosis, highlighting its role in cancer diagnostics and therapeutic targeting.
Additionally, MCM6 antibodies aid in studying replication stress and cell cycle regulation, particularly during the G1/S phase transition. Dysregulation of MCM6 is linked to genomic instability and diseases like cancer. Commercial MCM6 antibodies are typically validated for specificity and sensitivity, ensuring reliable detection across experimental models. Their applications extend to understanding developmental biology, stem cell dynamics, and responses to DNA damage, cementing MCM6 as a pivotal focus in cellular and molecular research.
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