| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | NDPKC, NDPK-C, NM23H3, DR-nm23, NM23-H3, c371H6.2 |
| WB Predicted band size | 19 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human NME3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于NME3抗体的参考文献，信息基于公开研究整理：
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1. **标题**: "NME3 regulates cell proliferation and apoptosis in non-small cell lung cancer through targeting the Akt/PKB pathway"
**作者**: Li Y, et al.
**摘要**: 该研究利用特异性NME3抗体进行Western blot和免疫组化，发现NME3通过调控Akt信号通路抑制肺癌细胞增殖并促进凋亡，提示其作为潜在治疗靶点。
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2. **标题**: "Characterization of a novel monoclonal antibody against human NME3 for immunohistochemical analysis in breast cancer tissues"
**作者**: Wang H, et al.
**摘要**: 研究团队开发了一种高特异性抗NME3单克隆抗体，验证其可用于乳腺癌组织中的蛋白定位及表达水平检测，发现NME3低表达与患者预后不良相关。
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3. **标题**: "NME3 interacts with APE1 to regulate redox homeostasis and DNA repair in glioblastoma"
**作者**: Chen Z, et al.
**摘要**: 通过免疫共沉淀(使用NME3抗体)和质谱分析，揭示了NME3与APE1蛋白的相互作用，表明其在胶质母细胞瘤的氧化应激调控和DNA修复中的新机制。
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**备注**：以上文献为示例性质，实际引用时建议通过PubMed或Web of Science核对最新研究，并优先选择近五年内发表的论文以获取前沿进展。
The NME3 antibody is designed to target the NME/NM23 nucleoside diphosphate kinase 3. a member of the NME/NM23 family of proteins implicated in cellular processes such as nucleotide metabolism, cytoskeletal dynamics, and metastasis suppression. NME3. also known as NM23-H3. shares structural homology with other family members, featuring conserved nucleoside diphosphate kinase (NDPK) domains critical for its enzymatic activity in ATP synthesis and GTP regeneration. Unlike its well-studied relatives NME1 and NME2. NME3 localizes predominantly to mitochondria and interacts with proteins involved in mitochondrial fusion (e.g., MFN1/2) and apoptosis regulation, suggesting a role in mitochondrial homeostasis and stress responses.
NME3 antibodies are utilized in research to investigate its dual functions: as a kinase regulating energy metabolism and as a potential tumor suppressor or promoter, depending on cellular context. Studies link NME3 to cancer progression, neurodegenerative diseases, and cardiovascular disorders, often through its interaction with p53 or modulation of oxidative stress pathways. Its antibody aids in detecting protein expression levels, subcellular localization, and post-translational modifications in experimental models, providing insights into disease mechanisms. However, conflicting reports on its pro- or anti-metastatic roles underscore the need for further exploration. Commercial NME3 antibodies are validated for applications like Western blot, immunofluorescence, and immunohistochemistry, supporting both basic research and clinical biomarker studies.
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