| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | OCT2; OTF2; Oct-2 |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human POU2F2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于POU2F2抗体的3篇参考文献示例(文献信息为模拟，供参考)：
---
1. **文献名称**：POU2F2 (Oct-2) regulates immunoglobulin gene expression in B cells via chromatin remodeling
**作者**：Smith J, et al.
**摘要**：本研究利用POU2F2特异性抗体进行染色质免疫沉淀(ChIP)，揭示了POU2F2通过结合免疫球蛋白基因启动子区域调控B细胞抗体类别转换的分子机制，证实其在体液免疫中的关键作用。
---
2. **文献名称**：Aberrant POU2F2 expression in diffuse large B-cell lymphoma detected by a novel monoclonal antibody
**作者**：Chen L, et al.
**摘要**：开发了一种高特异性抗POU2F2单克隆抗体，并通过免疫组化(IHC)和Western blot验证其在弥漫大B细胞淋巴瘤(DLBCL)样本中的异常高表达，提示其作为潜在诊断标志物的价值。
---
3. **文献名称**：POU2F2 antibody-based inhibition suppresses tumor growth in glioblastoma models
**作者**：Wang Y, et al.
**摘要**：研究采用POU2F2中和抗体阻断其转录活性，发现可显著抑制胶质母细胞瘤细胞的增殖和侵袭能力，表明靶向POU2F2可能是神经肿瘤治疗的新策略。
---
注：以上文献信息为示例性内容，实际引用时需根据真实文献调整。建议通过PubMed或Google Scholar以“POU2F2 antibody”及“Oct-2 antibody”为关键词检索最新研究。
The POU2F2 antibody targets the POU2F2 protein, also known as Oct-2. a member of the POU-domain transcription factor family. POU2F2 plays a critical role in regulating gene expression, particularly in B-cell development and immune response modulation. It binds to octamer motifs in DNA, facilitating the activation or repression of target genes involved in cell differentiation, proliferation, and apoptosis. Structurally, it contains a POU-specific domain and a POU homeodomain, enabling sequence-specific DNA interactions.
Research highlights its importance in B-cell-specific gene regulation, including immunoglobulin gene expression. Dysregulation of POU2F2 has been linked to certain cancers, autoimmune disorders, and neurological conditions, making it a focus for therapeutic and diagnostic studies. The antibody is widely used in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) to detect POU2F2 expression and localization in tissues or cell lines.
Available as monoclonal or polyclonal versions, POU2F2 antibodies are typically validated for specificity and sensitivity across species, including human, mouse, and rat. Commercial suppliers often provide datasheets detailing applications, dilution protocols, and storage conditions. Understanding POU2F2's role in cellular pathways continues to shed light on its interactions with co-regulators and its potential as a biomarker or drug target in disease contexts.
×
