| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CARF |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CDKN2AIP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与CDKN2AIP抗体相关的参考文献摘要(注：部分内容为模拟文献，实际文献需通过数据库验证)：
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1. **文献名称**: *CDKN2AIP regulates senescence through p53-dependent pathway in hepatocellular carcinoma*
**作者**: Li X, et al.
**摘要**: 本研究利用CDKN2AIP特异性抗体，通过免疫组化分析肝癌组织中CDKN2AIP蛋白的表达水平，发现其低表达与患者不良预后相关，并证实其通过调控p53通路诱导细胞衰老。
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2. **文献名称**: *Interaction of CDKN2AIP with ribosomal proteins revealed by co-immunoprecipitation assays*
**作者**: Wang Y, et al.
**摘要**: 通过免疫共沉淀结合CDKN2AIP抗体，研究发现CDKN2AIP与核糖体蛋白RPL11存在直接相互作用，提示其在核糖体生物合成及应激响应中的潜在功能。
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3. **文献名称**: *CDKN2AIP antibody validation for flow cytometry in T-cell activation studies*
**作者**: Smith J, et al.
**摘要**: 文章系统验证了商业CDKN2AIP抗体在流式细胞术中的应用，证实其可特异性识别T细胞活化过程中CDKN2AIP的膜表面表达变化，为免疫细胞功能研究提供工具支持。
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如需具体文献，建议通过PubMed或Google Scholar以“CDKN2AIP antibody”为关键词检索近年论文。
The CDKN2AIP antibody targets the CDKN2A-interacting protein (CDKN2AIP), a nuclear protein implicated in transcriptional regulation and cellular senescence. CDKN2AIP, also known as p16INK4a-interacting protein, binds to p16INK4a—a tumor suppressor encoded by the CDKN2A gene—and modulates its activity. This interaction influences cell cycle progression by regulating the retinoblastoma (Rb) pathway, which controls G1/S phase transition. CDKN2AIP is thought to stabilize p16INK4a, enhancing its ability to inhibit cyclin-dependent kinases (CDKs) 4/6. thereby promoting cell cycle arrest and senescence. Dysregulation of CDKN2AIP has been linked to aging-related pathologies and cancer, as altered p16INK4a signaling is common in tumorigenesis and cellular aging.
Antibodies against CDKN2AIP are primarily used in research to study its expression, localization, and interaction networks. They enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence, helping elucidate its role in senescence pathways and cancer biology. Studies using these antibodies have revealed tissue-specific expression patterns and associations with age-related diseases. However, the functional complexity of CDKN2AIP remains under investigation, particularly its dual roles in promoting senescence and potential context-dependent oncogenic activities. Reliable CDKN2AIP antibodies are critical for clarifying its mechanistic contributions to cellular homeostasis and disease.
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