| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | PAK5 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PAK6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于PAK6抗体的示例参考文献(内容为模拟虚构，仅供参考)：
1. **文献名称**：**"PAK6-specific antibody development and its application in prostate cancer research"**
**作者**：Chen L, et al.
**摘要**：本研究开发了一种高特异性PAK6单克隆抗体，通过免疫印迹和免疫组化验证其在人前列腺癌细胞中的表达，证实PAK6在肿瘤侵袭性表型中的调控作用。
2. **文献名称**：**"Role of PAK6 in neuronal differentiation revealed by antibody-mediated knockdown"**
**作者**：Sato K, et al.
**摘要**：利用PAK6抗体进行功能阻断实验，发现PAK6通过调控MAPK信号通路影响神经元突触形成，提示其在神经发育疾病中的潜在作用。
3. **文献名称**：**"PAK6 overexpression correlates with poor prognosis in colorectal cancer: an immunohistochemical study"**
**作者**：Wang Y, et al.
**摘要**：采用PAK6多克隆抗体对结直肠癌组织进行染色，发现PAK6高表达与患者生存率降低显著相关，提示其作为预后生物标志物的潜力。
4. **文献名称**：**"PAK6 antibody screening identifies novel interactions in breast cancer cell lines"**
**作者**：Garcia R, et al.
**摘要**：通过PAK6抗体共免疫沉淀结合质谱分析，揭示了PAK6与雌激素受体信号通路的相互作用，为乳腺癌靶向治疗提供新方向。
(注：以上文献为示例，实际引用需查询真实数据库如PubMed、Web of Science等。)
**Background of PAK6 Antibody**
The p21-activated kinase 6 (PAK6) is a serine/threonine kinase belonging to the PAK family, which comprises six members divided into two groups (Group I: PAK1-3; Group II: PAK4-6). PAK6. encoded by the *PAK6* gene, is primarily regulated by binding to Rho-family GTPases like Cdc42 and Rac. It plays roles in cytoskeletal reorganization, cell motility, transcriptional regulation, and signaling pathways, including MAPK and Wnt/β-catenin cascades. PAK6 is highly expressed in the brain, testes, and prostate, and has been implicated in neurological disorders, cancer progression, and androgen receptor signaling.
PAK6-specific antibodies are essential tools for studying its expression, localization, and function in physiological and pathological contexts. These antibodies are commonly validated for applications such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and co-immunoprecipitation (Co-IP). Due to structural similarities among PAK family members, high specificity is critical to avoid cross-reactivity. Researchers use PAK6 antibodies to explore its roles in diseases like prostate cancer, where it may promote metastasis or therapy resistance, and neurodegenerative conditions. Reliable antibodies enable the identification of PAK6 as a potential therapeutic target or biomarker in precision medicine.
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