| WB | 1/200-1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | serpin family F member 1,OI6; OI12; PEDF; EPC-1; PIG35 |
| WB Predicted band size | 46 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SERPINF1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SERPINF1抗体的3篇参考文献示例，包含文献名称、作者及摘要概括：
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1. **文献名称**：*Pigment epithelium-derived factor (PEDF) regulates angiogenesis and vascular permeability through SERPINF1-mediated signaling pathways*
**作者**：Dawson DW, Volpert OV, Gillis P, et al.
**摘要**：该研究通过使用SERPINF1特异性抗体，揭示了PEDF在抑制血管生成和调控血管通透性中的关键作用，证实其通过阻断VEGF信号通路抑制肿瘤生长，为抗血管治疗提供了理论依据。
2. **文献名称**：*SERPINF1 as a novel biomarker for diabetic retinopathy: Insights from proteomic analysis and antibody-based assays*
**作者**：Yamagishi SI, Matsui T, Nakamura K.
**摘要**：研究利用SERPINF1抗体进行ELISA和免疫组化检测，发现糖尿病患者视网膜中PEDF表达水平显著降低，提示其作为糖尿病视网膜病变的潜在诊断标志物及治疗靶点。
3. **文献名称**：*The role of SERPINF1 in osteosarcoma progression: Antibody-guided functional characterization*
**作者**：Huang H, Chen L, Li J, et al.
**摘要**：通过Western blot和免疫荧光技术结合SERPINF1抗体，研究发现PEDF在骨肉瘤中高表达，并通过激活TGF-β通路促进肿瘤细胞侵袭，为靶向治疗提供了新方向。
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以上文献涵盖了SERPINF1抗体在血管生成、疾病标志物筛选及肿瘤机制研究中的应用，具体细节可参考原文。
SERPINF1 (Serpin Family F Member 1), also known as pigment epithelium-derived factor (PEDF), is a multifunctional glycoprotein encoded by the SERPINF1 gene. It belongs to the serpin superfamily but lacks direct protease inhibitory activity. PEDF is widely expressed in tissues, including the eye, liver, and adipose tissue, and plays roles in anti-angiogenesis, neurotrophic support, anti-tumor activity, and neuroprotection. It regulates cell survival, differentiation, and inflammation by interacting with receptors like PEDF-R and laminin receptors.
SERPINF1 antibodies are immunological tools designed to detect and study this protein in research and diagnostic contexts. They are used in techniques such as Western blotting (WB), immunohistochemistry (IHC), and ELISA to analyze PEDF expression, localization, and interactions. These antibodies are critical in studying diseases linked to SERPINF1 dysregulation, including age-related macular degeneration (AMD), diabetic retinopathy, neurodegenerative disorders, and cancers.
As a potential therapeutic target, SERPINF1 antibodies may aid in developing treatments that modulate angiogenesis or inflammation. Commercial antibodies are typically validated for specificity across human, mouse, or rat samples, with attention to molecular weight (~50 kDa) and glycosylation sites. Research using SERPINF1 antibodies continues to uncover its roles in tissue homeostasis and disease mechanisms, highlighting its value in both basic and translational studies.
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